Land: USA
Sprog: engelsk
Kilde: NLM (National Library of Medicine)
Furosemide (UNII: 7LXU5N7ZO5) (Furosemide - UNII:7LXU5N7ZO5)
Merck Sharp & Dohme Corp.
Furosemide
Furosemide 50 mg in 1 mL
INTRAMUSCULAR
PRESCRIPTION
Dogs, Cats & Horses: Salix® is an effective diuretic possessing a wide therapeutic range. Pharmacologically it promotes the rapid removal of abnormally retained extracellular fluids. The rationale for the efficacious use of diuretic therapy is determined by the clinical pathology producing the edema. Salix® is indicated for the treatment of edema, (pulmonary congestion, ascites) associated with cardiac insufficiency and acute noninflammatory tissue edema. The continued use of heart stimulants, such as digitalis or its glycosides is indicated in cases of edema involving cardiac insufficiency. Cattle: Salix® is indicated for the treatment of physiological parturient edema of the mammary gland and associated structures. Salix® is a highly effective diuretic-saluretic which if given in excessive amounts may result in dehydration and electrolyte imbalance. Therefore, the dosage and schedule may have to be adjusted to the patient's needs. The animal should be observed for early signs of electrolyte imbalance, a
Salix® (furosemide injection) 5% Each mL contains: 50 mg furosemide as a diethanolamine salt preserved and stabilized with myristyl-gamma-picolinium chloride 0.02%, EDTA sodium 0.1%, sodium sulfite 0.1% with sodium chloride 0.2% in distilled water, pH adjusted with sodium hydroxide. Available in 50 mL multidose vials. Store between 15° and 30°C (59° and 86°F). Protect from freezing. Protect from light. Use contents within 28 days of first vial puncture.
New Animal Drug Application
SALIX- FUROSEMIDE INJECTION MERCK SHARP & DOHME CORP. ---------- SALIX (FUROSEMIDE INJECTION) 156707 R2 FOR VETERINARY USE ONLY A DIURETIC-SALURETIC FOR PROMPT RELIEF OF EDEMA. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION Salix (furosemide injection) is a chemically distinct diuretic and saluretic pharmacodynamically characterized by the following: 1) 2) 3) 4) 5) The intravenous route produces the most rapid diuretic response. The CAS Registry Number is 54-31-9. Salix , a diuretic, is an anthranilic acid derivative with the following structural formula: Generic name: Furosemide (except in United Kingdom-furosemide). Chemical name: 4-chloro-N- furfuryl-5-sulfamoylanthranilic acid. ACTIONS The therapeutic efficacy of Salix is from the activity of the intact and unaltered molecule throughout the nephron, inhibiting the reabsorption of sodium not only in the proximal and distal tubule but also in the ascending limb of the loop of Henle. The prompt onset of action is a result of the drug's rapid absorption and a poor lipid solubility. The low lipid solubility and a rapid renal excretion minimize the possibility of its accumulation in tissues and organs or crystalluria. Salix has no inhibitory effect on ® ® A high degree of efficacy, low-inherent toxicity and a high therapeutic index. A rapid onset of action and of comparatively short duration. 1,2 A pharmacological action in the functional area of the nephron, i.e., proximal and distal tubules and the ascending limb of the loop of Henle. 2,3,4 A dose-response relationship and a ratio of minimum to maximum effective dose range greater than tenfold. 1,2 It may be administered orally or parenterally. It is readily absorbed from the intestinal tract and well tolerated. ® ® ® carbonic anhydrase or aldosterone activity in the distal tubule. The drug possesses diuretic activity either in presence of acidosis or alkalosis. INDICATIONS Dogs, Cats & Horses: Salix is an effective diuretic possessing a wide therap Læs hele dokumentet