PROTRIN DF TAB TABLET

Land: Canada

Sprog: engelsk

Kilde: Health Canada

Aktiv bestanddel:

TRIMETHOPRIM; SULFAMETHOXAZOLE

Tilgængelig fra:

PRO DOC LIMITEE

ATC-kode:

J01EE01

INN (International Name):

SULFAMETHOXAZOLE AND TRIMETHOPRIM

Dosering:

160MG; 800MG

Lægemiddelform:

TABLET

Sammensætning:

TRIMETHOPRIM 160MG; SULFAMETHOXAZOLE 800MG

Indgivelsesvej:

ORAL

Enheder i pakken:

100/500

Recept type:

Prescription

Terapeutisk område:

URINARY ANTI-INFECTIVES

Produkt oversigt:

Active ingredient group (AIG) number: 0208901003; AHFS:

Autorisation status:

CANCELLED POST MARKET

Autorisation dato:

2017-05-05

Produktets egenskaber

0
PRODUCT MONOGRAPH
PROTRIN - DF
SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS USP 800/160 MG
ANTIBACTERIAL AGENT
PRO DOC LTÉE
DATE OF REVISION:
2925, boul. Industriel.
August 27, 2014
Laval, Québec
H7L 3W9
CONTROL NO.: 176738
1
PRODUCT MONOGRAPH
PROTRIN - DF, SULFAMETHOXAZOLE AND TRIMETHOPRIM TABLETS USP 800/160 MG
ANTIBACTERIAL AGENT
CLINICAL PHARMACOLOGY
PROTRIN (sulfamethoxazole and trimethoprim) is an antibacterial agent
with a wide spectrum of
activity. It contains two active antibacterial components,
sulfamethoxazole and trimethoprim,
which act synergistically on many species of bacteria.
FIGURE 1
Sulfamethoxazole and trimethoprim act sequentially in two successive
steps in the biosynthesis
of nucleic acids. Trimethoprim is an inhibitor of dihydrofolate
reductase, the enzyme which
reduces dihydrofolic acid to its tetrahydro form. This biochemical
step is essential in the
production of the folate coenzymes which are involved in the
biosynthesis of thymine, purine,
2
serine and methionine. Sulfamethoxazole exerts its antibacterial
activity by competing with para-
aminobenzoic acid.
Most pathogenic bacteria meet their need for dihydrofolic acid by
synthesizing it from para-
aminobenzoic acid, pteridine and glutamic acid. Animals, in contrast,
depend on exogenous
sources for their needs of folic acid and do not rely upon
intracellular synthesis.
Under usual circumstances, sulfamethoxazole or trimethoprim acting
alone do not produce
complete block in this biosynthesis of nucleic acids. Instead, they
cause sufficient reduction in the
synthesis of folate coenzymes to produce bacteriostasis. When the two
agents act together, the
superimposition of their effects produces a complete block in the
synthesis, leading to death of
the
organism.
Thus
the
effect
of
the
dual
action
is
to
reduce
the
minimum
inhibitory
concentrations (MIC) of each agent (synergism) and to convert a
bacteriostatic action to a
bactericidal action.
The activity of PROTRIN therefore depends upon the ability of both
sulfamethoxazole and
trimethoprim