FLURISO- isoflurane liquid

Land: USA

Sprog: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv bestanddel:

ISOFLURANE (UNII: CYS9AKD70P) (ISOFLURANE - UNII:CYS9AKD70P)

Tilgængelig fra:

MWI Veterinary Supply Co

INN (International Name):

ISOFLURANE

Sammensætning:

ISOFLURANE 1 mL in 1 mL

Indgivelsesvej:

RESPIRATORY (INHALATION)

Recept type:

PRESCRIPTION

Terapeutiske indikationer:

Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs. Isoflurane, USP is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.

Produkt oversigt:

Fluriso (Isoflurane, USP) is packaged in 100 mL (NDC 13985-528-40) and 250 mL (NDC 13985-528-60) amber-colored bottles. Store at room temperature 20o to 25o C (68o to 77o F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].

Autorisation status:

Abbreviated New Animal Drug Application

Produktets egenskaber

FLURISO - ISOFLURANE LIQUID
MWI VETERINARY SUPPLY CO
----------
WARNING: NOT FOR USE IN HORSES INTENDED FOR FOOD.
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Isoflurane, USP is a nonflammable, nonexplosive general inhalation
anesthetic agent. Its
chemical name is l-chloro-2,2,2-trifluoroethyl difluoromethyl ether,
and its structural
formula is:
Each mL contains 99.9% isoflurane.
Some physical constants are:
Molecular weight 184.5
Boiling point at 760 mm Hg 48.5° C (uncorr.)
Refractive index n 20
1.2990-1.3005
Specific gravity 25°/25° C 1.496
Vapor pressure in mm Hg** 20° C 238
25° C 295
30° C 367
35° C 450
**Equation for vapor pressure calculation:
D
log
_P_
= A + B/T
where: A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)
Partition coefficients at 37° C:
Water/gas 0.61
Blood/gas 1.43
Oil/gas 90.8
Partition coefficients at 37°
C
Water/gas
0.61
Blood/gas
1.43
Oil/gas
90.8
Partition coefficients at 25° C - rubber and plastic:
Conductive rubber/gas 62.0
Butyl rubber/gas 75.0
Polyvinyl chloride/gas 110.0
Polyethylene/gas ~2.0
Polyurethane/gas ~1.4
Polyolefin/gas ~1.1
Butyl acetate/gas ~2.5
Purity by gas chromatography >99.9%
Lower limit of flammability in oxygen or None
nitrous oxide at 9 joules/sec. and 23° C
Lower limit of flammability in oxygen or Greater than useful
concentration in
anesthesia
nitrous oxide at 900 joules/sec. and 23° C
MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in
dogs.
Isoflurane is a clear, colorless, stable liquid containing no
additives or chemical
stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor.
Samples stored in
10_ vap_
1
6
indirect sunlight in clear, colorless glass for five years, as well as
samples directly
exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V.
light were
unchanged in composition as determined by gas chromatography.
Isoflurane in one
normal sodium methoxide-methanol solution, a strong base, for over six
months
consumed essentially no alkali, in