Land: Australien
Sprog: engelsk
Kilde: Department of Health (Therapeutic Goods Administration)
dorzolamide hydrochloride,timolol maleate
Sandoz Pty Ltd
Dorzolamide hydrochloride,Timolol maleate
Registered
DORZOLAMIDE/ TIMOLOL SANDOZ ® 20/5 _dorzolamide hydrochloride / timolol maleate eye drops_ CONSUMER MEDICINE INFORMATION WHAT IS IN THIS LEAFLET This leaflet answers some common questions about DORZOLAMIDE/ TIMOLOL SANDOZ 20/5. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking this medicine against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again. WHAT DORZOLAMIDE/ TIMOLOL SANDOZ 20/5 IS USED FOR DORZOLAMIDE/TIMOLOL SANDOZ 20/5 is used to lower raised pressure in the eye and to treat glaucoma. Glaucoma is a condition in which the pressure of fluid in the eye may be high. However, some people with glaucoma may have normal eye pressure. Also, some people with raised eye pressure may not have glaucoma. Glaucoma is usually caused by a build-up of the fluid which flows through the eye. This build up occurs because the fluid drains out of your eye more slowly than it is being pumped in. Since new fluid continues to enter the eye, joining the fluid already there, the pressure continues to rise. This raised pressure may damage the back of the eye resulting in gradual loss of sight. Damage can progress so slowly that the person is not aware of this gradual loss of sight. Sometimes even normal eye pressure is associated with damage to the back of the eye. There are usually no symptoms of glaucoma. The only way of knowing that you have glaucoma is to have your eye pressure, optic nerve and visual field checked by an eye specialist or optometrist. If glaucoma is not treated it can lead to serious problems. You may have no symptoms but eventually glaucoma can lead to total blindness. In fact, untreated glaucoma is one of the most common causes of blindness. Although DORZOLAMIDE/ TIMOLOL SANDOZ 20/5 helps control your glaucoma Læs hele dokumentet
_Product Information _ _ _ _Page 1 _ _Dorzolamide/Timolol Sandoz 20/5 eye drops _ _08/2017 _ _Sandoz Pty Ltd _ _ _ _Version 01 _ PRODUCT INFORMATION DORZOLAMIDE/TIMOLOL SANDOZ ® 20/5 EYE DROPS NAME OF THE MEDICINE _ _ dorzolamide (as hydrochloride) and timolol (as maleate) _Dorzolamide hydrochloride _ Chemical name: (4 _S_ - _trans_ )-4-(ethylamino)-5,6-dihydro-6-methyl-4 _H_ -thieno [2,3- _b_ ]thiopyran-2-sulfonamide 7,7-dioxide monohydrochloride. Chemical structure : CAS [130693-82-2] Empirical formula: C 10 H 17 N 2 O 4 S 3 Cl MW: 360.91 _Timolol maleate _ Chemical name: (S)-1-[(1,1-dimethylethyl)amino]-3-[[4-(4-morpholinyl)- 1,2,5-thiadiazol-3-yl]oxy]-2-propanol,( _Z_ )-2-butenedioate (1:1) (salt). Chemical structure : CAS [26921-17-5] Empirical formula: C 13 H 24 N 4 O 3 SC 4 H 4 O 4 MW: 432.50 _Product Information _ _ _ _Page 2 _ _Dorzolamide/Timolol Sandoz 20/5 eye drops _ _08/2017 _ _Sandoz Pty Ltd _ _ _ _Version 01 _ DESCRIPTION _ _ Dorzolamide hydrochloride is a white to off-white, free flowing crystalline powder, which is soluble in water and slightly soluble in methanol and ethanol. Timolol maleate is a white, odourless, crystalline powder which is soluble in water, methanol, and alcohol. _ _ Each millilitre of Dorzolamide/Timolol Sandoz 20/5 contains 20.00 mg dorzolamide (22.26 mg of dorzolamide hydrochloride) and 5.00 mg timolol (6.83 mg of timolol maleate) as the active ingredients. It also contains the following inactive ingredients: sodium citrate, hydroxyethylcellulose, sodium hydroxide, mannitol, and water for injections. Benzalkonium chloride (0.0075%) is added as preservative. _ _ _ _ PHARMACOLOGY _ _ Mechanism of action Dorzolamide/Timolol Sandoz 20/5 is comprised of two components: dorzolamide hydrochloride and timolol maleate. It is the first combination of a topical carbonic anhydrase inhibitor and a topical beta-adrenergic receptor blocking agent. Each of these two components decreases elevated intraocular pressure by reducing aqueous humor secretion, but does so by a different mechanis Læs hele dokumentet