Land: USA
Sprog: engelsk
Kilde: NLM (National Library of Medicine)
DEXAMETHASONE (UNII: 7S5I7G3JQL) (DEXAMETHASONE - UNII:7S5I7G3JQL)
Clipper Distributing Company, LLC
DEXAMETHASONE
DEXAMETHASONE 2 mg in 1 mL
INTRAMUSCULAR
PRESCRIPTION
DEXAMETHASONE INJECTION 2 mg/mL is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine. As supportive therapy, DEXAMETHASONE INJECTION 2 mg/mL may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids. DEXAMETHASONE INJECTION 2 mg/mL may be used intravenously as supportive therapy when an immediate hormonal response is required. Bovine Ketosis DEXAMETHASONE INJECTION 2 mg/mL is offered for the treatment of primary ketosis. The gluconeogenic effects of DEXAMETHASONE INJECTION 2 mg/mL, when administered intramuscularly, are generally noted within the first 6 to 12 hours. When DEXAMETHASONE INJECTION 2 mg/mL is used intravenously, the effects may be noted sooner. Blood sugar levels rise to normal levels rapidly and generally rise to above normal levels within 12 to 24 hours. Acetone bodies are reduced to normal concentrations usually within 24 hours. The p
DEXAMETHASONE INJECTION 2 mg/mL, 100 mL multiple dose vial. Store at 20°C to 25°C (68°F to 77°F), excursions permitted between 15°C and 30°C (between 59°F and 86°F) Protect from freezing. ANADA#: 200-324, Approved by FDA
Abbreviated New Animal Drug Application
DEXAMETHASONE - DEXAMETHASONE INJECTION, SOLUTION CLIPPER DISTRIBUTING COMPANY, LLC ---------- DEXAMETHASONE INJECTION 2 MG/ML SOLUTION FOR INTRAVENOUS OR INTRAMUSCULAR INJECTION VETERINARY FOR ANIMAL USE ONLY MULTIPLE DOSE VIAL ANADA 200-324, APPROVED BY FDA CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION DEXAMETHASONE INJECTION 2 mg/mL is a synthetic analogue of prednisolone, having similar but more potent anti-inflammatory therapeutic action and diversified hormonal and metabolic effects. Modification of the basic corticoid structure as achieved in DEXAMETHASONE INJECTION 2 mg/mL offers enhanced anti-inflammatory effect compared to older corticosteroids. The dosage of DEXAMETHASONE INJECTION 2 mg/mL required is markedly lower than that of prednisone and prednisolone. DEXAMETHASONE INJECTION 2 mg/mL is not species-specific; however, the veterinarian should read the sections of INDICATIONS, DOSAGE, SIDE EFFECTS, CONTRAINDICATIONS, PRECAUTIONS, and WARNINGS before this drug is used. DEXAMETHASONE INJECTION 2 mg/mL is intended for _intramuscular _administration. Each mL contains 2 mg dexamethasone, 500 mg polyethylene glycol 400, 9 mg benzyl alcohol, 1.8 mg methylparaben and 0.2 mg propylparaben as preservatives, 4.75% alcohol, HCl in adjust pH to approximately 4.9 , water for injection q.s. EXPERIMENTAL STUDIES Experimental animal studies on dexamethasone have revealed it possesses greater anti-inflammatory activity than many steroids. Veterinary clinical evidence indicates dexamethasone has approximately twenty times the anti-inflammatory activity of prednisolone and seventy to eighty times that of hydrocortisone. Thymus involution studies show dexamethasone possesses twenty-five times the activity of prednisolone. In reference to mineralocorticoid activity, dexamethasone does not cause significant sodium or water retention. Metabolic balance studies show that animals on controlled and limited protein intake will exhibit nitrogen losses on exceedingly hi Læs hele dokumentet