Clamoxon S Injection

Land: Malaysia

Sprog: engelsk

Kilde: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktiv bestanddel:

Amoxicillin (as Trihydrate); Gentamicin (as sulphate)

Tilgængelig fra:

RANGE PHARMA SDN. BHD.

INN (International Name):

Amoxicillin (as Trihydrate); Gentamicin (as sulphate)

Fremstillet af:

RANGE PHARMA SDN. BHD.

Produktets egenskaber

CLAMOXON S INJECTION
DESCRIPTION AND COMPOSITION
CLAMOXON S INJECTION is an off white to grayish yellow oily
suspension. Each ml contains 150mg
of Amoxicillin (as trihydrate) and 40mg Gentamicin (as sulphate) as
its active ingredients and 50mg
Benzyl alcohol as preservative.
PHARMACODYNAMICS
Amoxicillin is a bactericidal antibiotic belonging to the group of
penicillins. It inhibits mucopeptide
synthesis, one of the rigid components of bacterial cell wall that
gives mechanical stability to the
bacterium, destroying bacteria in the growth phase.
Gentamicin is an aminoglycoside antibiotic that acts directly on the
ribosome, in which it inhibits protein
biosynthesis. Gentamicin penetration in the cell increases as the
permeability of the bacterial cell wall
is altered by amoxicillin. This allows the use of aminoglycoside
smaller quantities.
Amoxicillin and gentamicin together have a broad antibacterial
spectrum, including Gram positive
(corynebacteria) and Gram negative bacteria (_E. coli, Pasteurella_
spp. and _ Salmonella_ spp.) Its
association improving the therapeutic properties of each of these
antibiotics administered alone.
PHARMACOKINETICS
Amoxicillin is well absorbed after parenteral administration. 17-20%
of the active substance is bound to
plasma proteins. It is excreted primarily in the urine unchanged and
to a lesser extent for milk and bile.
Gentamicin is poorly absorbed from the gastrointestinal tract,
however, it is well absorbed after
parenteral
administration.
It
is
rapidly
distributed
reaching
kidney,
liver,
lung,
endometria
and
parenchyma. It has biphasic excretion, first rapid phase corresponding
to the distribution of the active
substance in the tissue and the second phase corresponding to the slow
release of the active substance
tissues to the plasma and subsequent elimination from the plasma.
INDICATION
Cattle:
For the treatment of pneumonia caused by strains of _ Pasteurella
multocida_ and _ Arcanobacterium _
_pyogenes_ sensitive to amoxicillin and gentamicin.
For the treatment of diarrhoea c