Chemmart Isosorbide Mononitrate

Land: Australien

Sprog: engelsk

Kilde: Department of Health (Therapeutic Goods Administration)

Aktiv bestanddel:

Isosorbide mononitrate

Tilgængelig fra:

Apotex Pty Ltd

Klasse:

Medicine Registered

Indlægsseddel

CHEMMART ISOSORBIDE
MONONITRATE TABLETS

_contains the active ingredient, Isosorbide mononitrate_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE. ASK YOUR
DOCTOR OR PHARMACIST IF YOU DO NOT
UNDERSTAND ANYTHING OR ARE
WORRIED ABOUT TAKING YOUR
MEDICINE.
This leaflet answers some of the
common questions people ask about
Isosorbide Mononitrate Sustained-
Release tablets.
It does not contain all the information
that is known about isosorbide
mononitrate.
It does not take place of talking to
your doctor or pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. Some more recent
information on your medicine may
be available. Speak to your
pharmacist or doctor to obtain the
most up-to-date information.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking isosorbide
monontrate against the benefits they
expect it will have for you.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT IS ISOSORBIDE
MONONITRATE USED FOR
The name of your medicine is
Chemmart Isosorbide Mononitrate
Sustained-Release tablets. It is used
to prevent angina.
Angina is a pain or uncomfortable
feeling in the chest, often spreading
to the arms or the neck and
sometimes to the shoulders and back.
This is caused by to little blood and
oxygen getting to the heart.
The pain of angina is usually brought
on by exercise or stress.
_HOW IT WORKS_
Isosorbide mononitrate belongs to a
group of medicines called nitrates. It
works by relaxing the blood vessels,
letting more blood and oxygen reach
the heart.
It is not recommended that isosorbide
mononitrate be taken for the
treatment of acute attacks.
Your doctor will have explained why
you are being treated with isosorbide
mononitrate and told you what dose
to take.
FOLLOW ALL DIRECTIONS GIVEN TO YOU
BY YOUR DOCTOR CAREFULLY.
They may differ from the
information contained in this leaflet.
However, your doctor may prescribe
this medicine for

Produktets egenskaber

Product Information – Australia 
CHEMMART ISOSORBIDE MONONITRATE TABLETS 

NAME OF THE MEDICINE 
Isosorbide Mononitrate Sustained Release Tablets. 

Chemical Name:  
1,4:3,6-dianhydro-D-glucitol 5-nitrate. 

Chemical 
Structure: 

Molecular Formula:  
C
6
H
9
NO
6

Molecular Weight:  
191.14 

CAS Registry Number:   
16051-77-7 

DESCRIPTION 
Isosorbide mononitrate is a white to pale yellow,
crystalline, odourless powder that is freely soluble in 
water. 

PHARMACOLOGY 
Isosorbide mononitrate is an active metabolite of
isosorbide dinitrate and exerts qualitatively similar effects. 
Isosorbide mononitrate reduces the workload of the heart by producing
venous and arterial dilatation. By 
reducing the end diastolic pressure and volume,
isosorbide mononitrate lowers intramural pressure, hence 
leading to an improvement in the sub-endocardial blood flow. The net
effect when administering isosorbide 
mononitrate is therefore a reduced workload for the heart and an
improvement in the oxygen 
supply/demand balance of myocardium. 

Nitrates are highly effective in the prophylaxis of symptomatic and
asymptomatic myocardial ischaemia. 
Nitrates dilate coronary arteries not only in pre- and post-stenotic
vessels, but also in eccentric lesions. 
The natural initiator of vascular relaxation is thought to be
endothelium derived relaxing factor (EDRF), 
which has both the clinical and biological characteristics of nitric
oxide. Organic nitrates are metabolised to 
nitric oxide in the muscle cell via a sulfhydryl dependent mechanism.
They are therefore thought to be the 
physiological substitute for EDRF. 

PHARMACOKINETICS 
Isosorbide mononitrate has an elimination half-life of around 5
hours. Isosorbide Mononitrate 60 mg 
Sustained Release Tablets provide a sustained release presentation
of isosorbide mononitrate, with 
approximately 85% bioavailability. The release mechanism in Chemmart
Isosorbide Mononitrate 
comprises acti