BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE tablet coated

Land: USA

Sprog: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv bestanddel:

BISOPROLOL FUMARATE (UNII: UR59KN573L) (BISOPROLOL - UNII:Y41JS2NL6U)

Tilgængelig fra:

Bryant Ranch Prepack

INN (International Name):

BISOPROLOL FUMARATE

Sammensætning:

BISOPROLOL FUMARATE 2.5 mg

Recept type:

PRESCRIPTION DRUG

Autorisation status:

Abbreviated New Drug Application

Produktets egenskaber

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE- BISOPROLOL FUMARATE AND
HYDROCHLOROTHIAZIDE TABLET, COATED
BRYANT RANCH PREPACK
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BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE TABLETS
DESCRIPTION
Bisoprolol fumarate and hydrochlorothiazide tablets are indicated for
the treatment of hypertension. It
combines two antihypertensive agents in a once-daily dosage: a
synthetic beta1-selective
(cardioselective) adrenoceptor blocking agent (bisoprolol fumarate)
and a benzothiadiazine diuretic
(hydrochlorothiazide).
Bisoprolol fumarate USP is chemically described as
(±)-1-[4-[[2-(1-methylethoxy)
ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol(_E_)-2-butenedioate
(2:1) (salt). It
possesses an asymmetric carbon atom in its structure and is provided
as a racemic mixture. The S(-)
enantiomer is responsible for most of the beta-blocking activity. Its
empirical formula is
(C
H NO ) •C H O and it has a molecular weight of 766.97. Its
structural formula is:
Bisoprolol fumarate USP is a white crystalline powder, approximately
equally hydrophilic and
lipophilic, and readily soluble in water, methanol, ethanol, and
chloroform.
Hydrochlorothiazide USP (HCTZ) is
6-Chloro-3,4-dihydro-2_H_-1,2,4-benzothiadiazine-7-sulfonamide
1,1-dioxide. It is a white, or practically white, practically odorless
crystalline powder. It is slightly
soluble in water, sparingly soluble in dilute sodium hydroxide
solution, freely soluble in n-butylamine
and dimethylformamide, sparingly soluble in methanol, and insoluble in
ether, chloroform, and dilute
mineral acids. Its empirical formula is C H CIN O S and it has a
molecular weight of 297.73. Its
structural formula is:
Each Bisoprolol Fumarate and Hydrochlorothiazide Tablet, 2.5 mg/6.25
mg for oral administration
contains:
Bisoprolol fumarate
USP....................................................................................................2.5
mg
18
31
4 2
4
4
4
7
8
3
4
2
Hydrochlorothiazide USP
............................................................................................