BEUTHANASIA-D SPECIAL- pentobarbital sodium and phenytoin sodium injection, solution

Land: USA

Sprog: engelsk

Kilde: NLM (National Library of Medicine)

Aktiv bestanddel:

pentobarbital sodium (UNII: NJJ0475N0S) (pentobarbital - UNII:I4744080IR), phenytoin sodium (UNII: 4182431BJH) (phenytoin - UNII:6158TKW0C5)

Tilgængelig fra:

Merck Sharp & Dohme Corp.

Indgivelsesvej:

INTRACARDIAC

Recept type:

PRESCRIPTION

Terapeutiske indikationer:

FOR DOGS ONLY NADA #119-807 PRODUCT INFORMATION CAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian. INDICATIONS For use in dogs for humane, painless, and rapid euthanasia.

Produkt oversigt:

HOW SUPPLIED BEUTHANASIA-D SPECIAL EUTHANASIA SOLUTION is available in 100-mL multiple-dose vials, NDC 0061-0473-05. Manufactured by a nonsterilizing process. STORAGE Store between 15° and 30°C (59° and 86°F).

Autorisation status:

New Animal Drug Application

Produktets egenskaber

BEUTHANASIA-D SPECIAL- PENTOBARBITAL SODIUM AND PHENYTOIN SODIUM
INJECTION, SOLUTION
MERCK SHARP & DOHME CORP.
----------
BEUTHANASIA -D
SPECIAL
(EUTHANASIA SOLUTION)
CIII
FOR DOGS ONLY
NADA #119-807
PRODUCT
INFORMATION
CAUTION Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION A nonsterile solution containing pentobarbital sodium and
phenytoin sodium as the
active ingredients. Rhodamine B, a bluish-red fluorescent dye, is
included in the formulation to help
distinguish it from parenteral drugs intended for therapeutic use.
Although the solution is not sterile,
benzyl alcohol, a bacteriostat, is included to retard the growth of
microorganisms.
EACH ML CONTAINS: _active ingredients:_ 390 mg pentobarbital sodium
(barbituric acid derivative), 50 mg
phenytoin sodium; _inactive ingredients:_ 10% ethyl alcohol, 18%
propylene glycol, 0.003688 mg
rhodamine B, 2% benzyl alcohol (preservative), purified water qs.
Sodium hydroxide and/or
hydrochloric acid may be added to adjust pH.
ACTIONS BEUTHANASIA-D SPECIAL EUTHANASIA SOLUTION contains two active
ingredients which are chemically compatible but pharmacologically
different. Each ingredient acts in
such a manner so as to cause humane, painless, and rapid euthanasia.
Euthanasia is due to cerebral death
in conjunction with respiratory arrest and circulatory collapse.
Cerebral death occurs prior to cessation
of cardiac activity.
When administered intravenously, pentobarbital sodium produces rapid
anesthetic action. There is a
smooth and rapid onset of unconsciousness. At the lethal dose, there
is depression of vital medullary
respiratory and vasomotor centers.
When administered intravenously, phenytoin sodium produces toxic signs
of cardiovascular collapse
and/or central nervous system depression. Hypotension occurs when the
drug is administered rapidly.
PHARMACODYNAMIC ACTIVITY: The sequence of events leading to humane,
painless, and rapid euthanasia
following intravenous injection of BEUTHANASIA-D SPECIAL EUTHANASIA
SOLUTION is