Land: Sydafrika
Sprog: engelsk
Kilde: South African Health Products Regulatory Authority (SAHPRA)
Adcock
ADCO-AMOXYCILLIN 125 mg/5 mL Suspension ADCO-AMOXYCILLIN 250 mg/5 mL Suspension ADCO-AMOXYCILLIN 250 mg Capsules ADCO-AMOXYCILLIN 500 mg Capsules SCHEDULING STATUS: S4 PROPRIETARY NAME: (and dosage form) ADCO-AMOXYCILLIN 125 mg/5 mL Suspension ADCO-AMOXYCILLIN 250 mg/5 mL Suspension ADCO-AMOXYCILLIN 250 mg Capsules ADCO-AMOXYCILLIN 500 mg Capsules COMPOSITION: Capsules: Each capsule contains amoxycillin trihydrate equivalent to 250 mg amoxycillin and 500 mg amoxycillin. Powder for Oral Suspension: The powder contains amoxycillin trihydrate equivalent to 125 mg or 250 mg amoxycillin per 5 mL and 0,1% m/v sodium benzoate as preservative when reconstituted. PHARMACOLOGICAL CLASSIFICATION: A. 20.1.2 Antimicrobial agents - Penicillins PHARMACOLOGICAL ACTION: Amoxycillin is a semi-synthetic, broad-spectrum penicillin derived from the 6-amino- penicillanic acid nucleus. Chemically it is 6-[D(-)-alpha-amino-p-hydroxyphenyl -acetamido] penicillanic acid trihydrate. Amoxycillin is rapidly absorbed after oral administration and provides high blood levels and very high concentrations in the tissues and urine. Amoxycillin does not readily diffuse into the brain and spinal fluid except when the meninges are inflamed. The ingestion of food does not greatly reduce the absorption of amoxycillin. Amoxycillin does not appear to be metabolized in the body. Urinary excretion is rapid, and only unchanged amoxycillin is recovered in the urine. Its excretion can be delayed by concurrent administration of probenecid. Approximately 17% of amoxycillin is bound by serum proteins. Amoxycillin does not resist destruction by penicillinase and is thus not effective against penicillinase-producing bacteria, particularly resistant Staphylococci. All strains of Pseudomonas and most strains of Klebsiella, indole-positive Proteus, Serratia, Læs hele dokumentet