VETMULIN 125MGML SOLUTION FOR USE IN DRINKING WATER

Země: Malajsie

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivní složka:

TIAMULIN HYDROGEN FUMARATE

Dostupné s:

PAHANG PHARMACY SDN. BHD.

INN (Mezinárodní Name):

TIAMULIN HYDROGEN FUMARATE

Jednotky v balení:

1 L; 5 L

Výrobce:

Biovet Joint Stock Company

Charakteristika produktu

®
VETMULIN 125 MG/ML
SOLUTION FOR USE IN DRINKING WATER
FOR PIGS AND CHICKENS
STATEMENT OF ACTIVE
SUBSTANCE:
Each gram contains Tiamulin hydrogen
fumarate 125.0 mg (equivalent to
tiamulin 101.2 mg)
PRODUCT DESCRIPTION:
®
Vetmulin 125 mg/ml Solution for use in
drinking water for pigs and chickens
represents a clear, colourless to slightly
yellow liquid.
PHARMACODYNAMICS:
Tiamulin is a bacteriostatic semi-synthetic
antibiotic belonging to the pleuromutilin
group of antibiotics and acts at the
ribosomal level to inhibit bacterial protein
synthesis. Tiamulin has shown a high
level of in vitro activity against porcine and
avian _ Mycoplasma species_ as well as
gram-positive aerobes (streptococci and
staphylococci), anaerobes (clostridia),
gram-negative anaerobes (_Brachyspira _
_hyodysenteriae, Brachyspira pilosicoli_),
and gram-negative aerobes (_Pasteurella _
_multocida_).
Tiamulin has been shown to act at the
70S ribosome level and the primary
binding sites are on the 50S subunit. It
appears to inhibit microbial protein
production by producing biochemically
inactive initiation complexes, which
prevent elongation of the polypeptide
chain. In European isolates of
_Brachyspira hyodysenteriae_ collected
between 1990 and 2012 the minimum
inhibitory concentration (MICs) ranged
from ≤0.016 µg/ml to >16 µg/ml, with
MIC50 of ≤0.063 µg/ml to 4 µg/ml and
MIC90 of ≤0.016 µg/ml to >16 µg/ml. In
European isolates of _ Brachyspira _
_pilosicoli_ the MICs ranged from (citation
from 2006-2008-2012) ≤0.008-64 µg/ml,
with MIC50s of ≤0.062 µg/ml up to 0.125
µg/ml and MIC90s of 0.25 µg/ml up to 8
µg/ml. Susceptibility testing of _Lawsonia _
_intracellularis_ is challenging since this is
an obligate intracellular organism. The
tiamulin MIC data determined for the
available EU _ Lawsonia _ strains were
(citation from 2017) all below the
estimated ileal tiamulin contents of 0.63
μg/ml.
In European isolates tiamulin was highly
a c t i v e a g a i n s t _ M y c o p l a s m a _
_hyopneumoniae_, with MIC50 of 0.016
µg