TRIHEXYPHENIDYL HYDROCHLORIDE- trihexyphenidyl hydrochloride tablet

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

TRIHEXYPHENIDYL HYDROCHLORIDE (UNII: AO61G82577) (TRIHEXYPHENIDYL - UNII:6RC5V8B7PO)

Dostupné s:

West-ward Pharmaceutical Corp

INN (Mezinárodní Name):

TRIHEXYPHENIDYL HYDROCHLORIDE

Složení:

TRIHEXYPHENIDYL HYDROCHLORIDE 2 mg

Podání:

ORAL

Druh předpisu:

PRESCRIPTION DRUG

Terapeutické indikace:

Trihexyphenidyl HCl tablets are indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.

Přehled produktů:

Trihexyphenidyl HCl Tablets USP, 2 mg: White, round, embossed "W4" on one side and scored on the other side.     Bottles of 100 tablets.     Bottles of 1000 tablets.     Unit Dose Boxes of 100 tablets. Trihexyphenidyl HCl Tablets USP, 5 mg: White, round, embossed "WW 763" on one side and scored on the other side.     Bottles of 100 tablets.     Bottles of 1000 tablets.     Unit Dose Boxes of 100 tablets.

Stav Autorizace:

Abbreviated New Drug Application

Charakteristika produktu

TRIHEXYPHENIDYL HYDROCHLORIDE- TRIHEXYPHENIDYL HYDROCHLORIDE TABLET
WEST-WARD PHARMACEUTICAL CORP
----------
TRIHEXYPHENIDYL
HYDROCHLORIDE TABLETS, USP
RX ONLY
DESCRIPTION
Trihexyphenidyl HCl is a synthetic antispasmodic. Each tablet, for
oral administration, contains 2 mg or
5 mg trihexyphenidyl HCl, and the following inactive ingredients:
Anhydrous Lactose, Colloidal
Silicon Dioxide, Corn Starch, Magnesium Stearate, and Microcrystalline
Cellulose.
Trihexyphenidyl HCl is a white or slightly off white, crystalline
powder, having not more than a very
faint odor.
Trihexyphenidyl HCl is chemically designated as
(±)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol
hydrochloride [52-49-3]. Its molecular formula is C
H NO•HCl, and the molecular weight is 337.93.
The structural formula is:
CLINICAL PHARMACOLOGY
Trihexyphenidyl exerts a direct inhibitory effect upon the
parasympathetic nervous system. It also has a
relaxing effect on smooth musculature; exerted both directly upon the
muscle tissue itself and indirectly
through an inhibitory effect upon the parasympathetic nervous system.
Its therapeutic properties are
similar to those of atropine although undesirable side effects are
ordinarily less frequent and severe
than with the latter.
INDICATIONS AND USAGE
Trihexyphenidyl HCl tablets are indicated as an adjunct in the
treatment of all forms of parkinsonism
(postencephalitic, arteriosclerotic, and idiopathic). It is often
useful as adjuvant therapy when treating
these forms of parkinsonism with levodopa. Additionally, it is
indicated for the control of
extrapyramidal disorders caused by central nervous system drugs such
as the dibenzoxazepines,
phenothiazines, thioxanthenes, and butyrophenones.
WARNINGS
Patients to be treated with trihexyphenidyl should have a gonioscope
evaluation and close monitoring of
intraocular pressures at regular periodic intervals.
20
31
PRECAUTIONS
Although trihexyphenidyl is not contraindicated for patients with
cardiac, liver, or kidney disorders, or
with hypertension, such patients shoul