TRIHEXYPHENIDYL HYDROCHLORIDE tablet

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

TRIHEXYPHENIDYL HYDROCHLORIDE (UNII: AO61G82577) (TRIHEXYPHENIDYL - UNII:6RC5V8B7PO)

Dostupné s:

Natco Pharma Limited

INN (Mezinárodní Name):

TRIHEXYPHENIDYL HYDROCHLORIDE

Složení:

TRIHEXYPHENIDYL HYDROCHLORIDE 2 mg

Podání:

ORAL

Druh předpisu:

PRESCRIPTION DRUG

Terapeutické indikace:

Trihexyphenidyl HCl is indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.  Trihexyphenidyl HCl is contraindicated in patients with hypersensitivity to trihexyphenidyl HCl or to any of the tablet ingredients. Trihexyphenidyl HCl is also contraindicated in patients with narrow angle glaucoma. Blindness after long-term use due to narrow angle glaucoma has been reported. Although trihexyphenidyl HCl is not classified as a controlled substance, the possibility of abuse should be borne in mind due to its stimulant and euphoriant properties.

Přehled produktů:

Trihexyphenidyl Hydrochloride Tablets, USP 2 mg are white colored, round debossed with N, T on either side of the score line and '2' on the other side.    Trihexyphenidyl Hydrochloride Tablets, USP 2 mg are available in   Bottle of 100 tablets (NDC 63850-0021-1)  Bottle of 250 tablets (NDC 63850-0021-2)  Bottle of 1000 tablets (NDC 63850-0021-3)  Trihexyphenidyl Hydrochloride Tablets, USP 5 mg are white colored, round debossed with N, T on either side of the score line and '5' on other side.  Trihexyphenidyl Hydrochloride Tablets, USP 5 mg are available in  Bottle of 100 tablets (NDC 63850-0022-1)  Bottle of 1000 tablets (NDC 63850-0022-2)  Dispense in a tight container with child-resistant closure. Store at 20°-25°C (68°- 77°F). [See USP controlled room temperature.] Manufactured by: NATCO PHARMALIMITED Kothur-509 228, A.P, India. Rev:  01/Sep/2010

Stav Autorizace:

Abbreviated New Drug Application

Charakteristika produktu

TRIHEXYPHENIDYL HYDROCHLORIDE- TRIHEXYPHENIDYL HYDROCHLORIDE TABLET
NATCO PHARMA LIMITED
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TRIHEXYPHENIDYL HYDROCHLORIDE TABLETS, USP
RX ONLY
DESCRIPTION
Trihexyphenidyl HCl is a synthetic antispasmodic drug. It is
designated chemically as α-Cyclohexylα-
phenyl-1-piperidinepropanol hydrochloride and its structural formula
is as follows:
Trihexyphenidyl HCl occurs as a white or creamy-white, almost
odorless, crystalline powder. It is very
slightly soluble in ether and benzene, slightly soluble in water and
soluble in methanol.
Trihexyphenidyl Hydrochloride Tablets USP 2 mg and 5 mg contain the
following inactive
ingredients: magnesium stearate, microcrystalline cellulose and sodium
starch glycolate.
CLINICAL PHARMACOLOGY
Trihexyphenidyl HCl exerts a direct inhibitory effect upon the
parasympathetic nervous system. It also
has a relaxing effect on smooth musculature; exerted both directly
upon the muscle tissue itself and
indirectly through an inhibitory effect upon the parasympathetic
nervous system. Its therapeutic
properties are similar to those of atropine although undesirable side
effects are ordinarily less frequent
and severe than with the latter.
INDICATIONS AND USAGE
Trihexyphenidyl HCl is indicated as an adjunct in the treatment of all
forms of parkinsonism
(postencephalitic, arteriosclerotic, and idiopathic). It is often
useful as adjuvant therapy when treating
these forms of parkinsonism with levodopa. Additionally, it is
indicated for the control of
extrapyramidal disorders caused by central nervous system drugs such
as the dibenzoxazepines,
phenothiazines, thioxanthenes, and butyrophenones.
CONTRAINDICATIONS
Trihexyphenidyl HCl is contraindicated in patients with
hypersensitivity to trihexyphenidyl HCl or to
any of the tablet ingredients. Trihexyphenidyl HCl is also
contraindicated in patients with narrow angle
glaucoma. Blindness after long-term use due to narrow angle glaucoma
has been reported.
WARNINGS
Patients to be treated with trihexyphenidyl HCl should have a
gonioscope evaluation p