TP-Coccilock Sol Sulfaquinoxaline 60mgml Solution

Země: Malajsie

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivní složka:

SULFAQUINOXALINE

Dostupné s:

Thye Pharma Sdn. Bhd

INN (Mezinárodní Name):

SULFAQUINOXALINE

Jednotky v balení:

5l kg

Výrobce:

Thye Pharma Sdn. Bhd

Charakteristika produktu

Veterinary Package Insert
TP-COCCILOCK SOL SULFAQUINOXALINE
60MG/ML
SOLUTION
(6%
Sulfaquinoxaline)
PRODUCT DESCRIPTION
TP-Coccilock
Sol
sulfaquinoxaline
60mg/ml
solution brown colour liquid, which contains 6%
sulfaquinoxaline, in 5 L bottle.
PHARMACODYNAMICS & PHARMACOKINETICS
Sulfaquinoxaline belongs to a group of antibiotics
called
the
sulphonamides.
It
is
bacteriostatic.
Sulfonamides
interfere
with
the
biosynthesis
of
folic acid in bacterial cells; they compete with para-
aminobenzoic acid (PABA) for incorporation in the
folic acid molecule. By replacing the PABA molecule
and preventing the folic acid formation required for
DNA
synthesis,
the
sulfonamides
prevent
multiplication of the bacterial cell. Only organisms
that synthesize their own folic acid are susceptible;
mammalian
cells
use
preformed
folic
acid
and,
therefore, are not susceptible. Cells that produce
excess PABA or environments with PABA, such as
necrotic
tissues,
allow
for
resistance
by
competition with the sulfonamide.
_Absorption _
Most sulfonamides are well absorbed orally with
the exception of the enteric sulfonamides, such as
sulfaquinoxaline,
which
are
minimally
absorbed.
Delays in absorption may occur in adult ruminants
or when sulfonamides are administered with food
to monogastric animals.
_Distribution _
Sulfonamides are widely distributed throughout the
body. They cross the placenta, and a few penetrate
into the cerebrospinal fluid. Sulfonamides may be
distributed into milk; however, they vary greatly in
their
ability
to
do
so.
The
process
depends
on
several factors, including protein binding and pKa
values.
_Protein Binding _
Binding
can
vary
depending
on
serum
concentration and other factors.
_Biotransformation _
Sulfonamides are primarily metabolized in the liver
but
metabolism
also
occurs
in
other
tissues.
Biotransformation
occurs
mainly
by
acetylation,
glucuronide
conjugation,
and
aromatic
hydroxylation
in
many
species.
The
types
of
metabolites formed and the amount of each varies
depending
on
the
specific
sulfonamide
administered;