Terry White Chemists Perindopril perindopril erbumine 4mg tablets blister pack

Země: Austrálie

Jazyk: angličtina

Zdroj: Department of Health (Therapeutic Goods Administration)

Aktivní složka:

perindopril erbumine

Dostupné s:

Apotex Pty Ltd

INN (Mezinárodní Name):

Perindopril erbumine

Třída:

Medicine Registered

Stav Autorizace:

Registered

Informace pro uživatele

TERRY WHITE CHEMISTS
PERINDOPRIL TABLETS
_Contains the active ingredient perindopril erbumine_
CONSUMER MEDICINE INFORMATION
_FOR A COPY OF A LARGE PRINT LEAFLET, PH: 1800 195 055_
WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE.
This leaflet answers some common
questions about perindopril. It does
not contain all the available
information about this medicine. It
does not take the place of talking to
your doctor or pharmacist.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information.
You can also download the most up
to date leaflet from
www.apotex.com.au.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is Terry
White Chemists Perindopril tablets.
It contains the active ingredient
perindopril erbumine.
Perindopril belongs to a group of
medicines called angiotensin
converting enzyme (ACE) inhibitors.
It is used to treat high blood pressure,
heart failure or coronary artery
disease.
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed this
medicine for another reason.
This medicine is available only with
a doctor's prescription.
_HIGH BLOOD PRESSURE_
Everyone has blood pressure. This
pressure helps to circulate blood all
around the body. Your blood
pressure may be different at different
times of the day, depending on how
busy or worried you are. You have
high blood pressure (also known as
hypertension) when your blood
pressure stays higher than is needed,
even when you are calm and relaxed.
There are usually no symptoms of
high blood pressure. The only way of
know

Charakteristika produktu

Product Information – Australia
Terry White chemists Perindopril Tablets
Page 1
TERRY WHITE CHEMISTS PERINDOPRIL TABLETS
NAME OF THE MEDICINE
Perindopril erbumine.
Chemical Name:
2-Methylpropan-2-amine (2_S_,3a_S_,7a_S_)-1-[(2_S_)-2-[[(1_S_)-1-
(ethoxycarbonyl)butyl]amino]propanoyl]octahydro-1_H_-indole-2-carboxylate
Structural Formula:
Molecular Formula:
C
19
H
32
N
2
O
5
,C
4
H
11
N
CAS Registry Number: 107133-36-8
DESCRIPTION
Perindopril is a dipeptide monoacid monoester with a perhydroindole
group and no sulfhydryl radical.
Perindopril erbumine is a white powder, readily soluble in purified
water, 95% ethanol and chloroform.
Perindopril has five asymmetric centres and is synthesised
stereoselectively so that it is a single
enantiomer (all S stereochemistry).
Perindopril erbumine is an angiotensin converting enzyme inhibitor.
Each tablet contains perindopril erbumine as the active ingredient. In
addition each tablet contains the
following inactive ingredients: lactose anhydrous and magnesium
stearate.
PHARMACOLOGY
PHARMACOLOGICAL ACTIONS
Perindopril (prodrug), following hydrolysis to perindoprilat, inhibits
angiotensin converting enzyme (ACE)
both in vitro and in vivo. It is thought that ACE inhibitors reduce
blood pressure by inhibiting the enzyme
which catalyses the conversion of angiotensin I to angiotensin II.
Decreased plasma angiotensin II leads
to increased plasma renin activity and a decrease in aldosterone. In
addition to its effects on circulating
ACE, perindopril binds to and inhibits tissue converting enzyme,
predominantly in the kidney and vascular
wall. The contribution of this mechanism to the overall
antihypertensive effect of perindopril is unknown.
Animal studies have demonstrated reversal of vascular hypertrophy and
an improvement in the ratio of
elastin to collagen in the vessel wall. Studies in humans have
demonstrated an improvement in the
viscoelastic properties of large vessels and in compliance. Studies in
animals and humans suggest that
specific and competitive suppression of the re