Terry White Chemists Clomipramine

Země: Austrálie

Jazyk: angličtina

Zdroj: Department of Health (Therapeutic Goods Administration)

Aktivní složka:

Clomipramine hydrochloride

Dostupné s:

Apotex Pty Ltd

Třída:

Medicine Registered

Informace pro uživatele

TERRY WHITE CHEMISTS
CLOMIPRAMINE

_Contains the active ingredient, clomipramine (as clomipramine
hydrochloride)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
READ THIS LEAFLET CAREFULLY BEFORE
TAKING YOUR MEDICINE
This leaflet answers some common
questions about clomipramine. It
does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
The information in this leaflet was
last updated on the date listed on the
last page. More recent information on
this medicine may be available.
ASK YOUR DOCTOR OR PHARMACIST:
•
if there is anything you do not
understand in this leaflet,
•
if you are worried about taking
your medicine, or
•
to obtain the most up-to-date
information
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using this medicine
against the benefits they expect it
will have for you.
Pharmaceutical companies cannot
give you medical advice or an
individual diagnosis.
Keep this leaflet with your medicine.
You may want to read it again.
WHAT THIS MEDICINE IS
USED FOR
The name of your medicine is Terry
White Chemists Clomipramine. It
contains the active ingredient,
clomipramine (as clomipramine
hydrochloride).
It is used to treat:
•
depression
•
obsessive compulsive disorders
and phobias in adults
•
cataplexy associated with
narcolepsy (sudden muscle
weakness associated with an
uncontrollable desire to sleep).
Ask your doctor if you have any
questions about why this medicine
has been prescribed for you. Your
doctor may have prescribed it for
another reason.
_HOW IT WORKS_
Clomipramine belongs to a group of
medicines called tricyclic
antidepressants.
These medicines are thought to work
by their action on brain chemicals
called amines which are involved in
controlling mood.
_USE IN CHILDREN_
There is not enough information to
recommend using this medicine in
children and adolescents younger
than 18 years.
BEFORE YOU TAKE THIS
MEDICINE
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE THIS MEDICINE IF:
�

Charakteristika produktu

Product Information – Australia 
Terry White Chemists Clomipramine Tablets 
Page 1 

TERRY WHITE CHEMISTS CLOMIPRAMINE TABLETS 

NAME OF THE MEDICINE 
Clomipramine hydrochloride 

Chemical Name; 
3-chloro-5-[3-(dimethylamino)-propyl]10, 11-dihydro-5H dibenz [b,f] azepine 

hydrochloride. 

Structural Formula: 

Molecular Formula:  C
19
 H
23
 N
2
Cl . HCl  

Molecular Weight: 
351.3 

CAS Registry Number:  17321-77-6 

DESCRIPTION 
Clomipramine is the 3-chloro derivative of imipramine.  It is a white crystalline powder, soluble in water, 
slightly soluble in ethanol and insoluble in diethyl ether. 

PHARMACOLOGY 
PHARMACODYNAMICS  
Clomipramine is a
tricyclic antidepressant.  It inhibits the neuronal re-uptake of noradrenaline (NA) and 
serotonin (5-HT) released in the
synaptic cleft, inhibition of 5-HT uptake being the
dominant component of 
this activity.  Clomipramine also has a wide
spectrum of pharmacological action, including alpha
1
-
adrenolytic, anticholinergic, antihistaminic and
antiserotonergic (5-HT-receptor blocking) properties. 

PHARMACOKINETICS 
Absorption 
The active substance is completely absorbed following oral administration, but due to extensive hepatic 
first pass metabolism to the active
metabolite, _N_-desmethylclomipramine,  less than 50% of a
dose 
reaches the systemic circulation unchanged. 

During oral administration of constant daily doses  of clomipramine, the steady-state plasma 
concentrations of clomipramine show wide variations between
patients.  Administration of the standard 
dose recommended for treatment of depression, _i.e._  25 mg clomipramine orally three times daily, 
produced steady state concentrations ranging from 31 ng/mL to 186
ng/mL.  This scatter reflects 
differences in clomipramine’s distribution volume and clearance bet