SYNCAINE- tricaine powder, for solution

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

TRICAINE METHANESULFONATE (UNII: 971ZM8IPK1) (TRICAINE - UNII:02591PHL19)

Dostupné s:

Western Chemical Inc.

INN (Mezinárodní Name):

TRICAINE METHANESULFONATE

Složení:

TRICAINE METHANESULFONATE 1000 mg in 1 g

Podání:

TOPICAL

Druh předpisu:

OTC

Terapeutické indikace:

SYNCAINE (tricaine methanesulfonate) KEEP TIGHTLY CLOSED USE ONLY FRESH SOLUTION Before using this drug, read package insert for complete product information. Store at room temperature (Approximately 25°C (77°F)) KEEP OUT OF THE REACH OF CHILDREN SYNCAINE is intended for the temporary immobilization of fish, amphibians, and other aquatic, cold-blooded animals (poikilotherms) as an aid in handling during manual spawning (fish stripping), weighing, measuring, marking, surgical operations, transport, photography, and research.

Stav Autorizace:

Abbreviated New Animal Drug Application

Charakteristika produktu

SYNCAINE- TRICAINE POWDER, FOR SOLUTION
WESTERN CHEMICAL INC.
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SYNCAINE
(TRICAINE METHANESULFONATE)
SYNCAINE
(tricaine methanesulfonate)
KEEP TIGHTLY CLOSED USE ONLY FRESH SOLUTION
Before using this drug, read package insert for complete
product information.
Store at room temperature (Approximately 25°C (77°F))
KEEP OUT OF THE REACH OF CHILDREN
SYNCAINE is intended for the temporary immobilization of fish,
amphibians, and other
aquatic, cold-blooded animals (poikilotherms) as an aid in handling
during manual
spawning (fish stripping), weighing, measuring, marking, surgical
operations, transport,
photography, and research.
WARNINGS
WARNINGS
Do not use within 21 days of harvesting fish for food. Use in fish
intended for food
should be restricted to Ictaluridae, Salmonidae, Esocidae, and
Percidae, and water
temperature exceeding 10ºC (50ºF). In other fish and in cold-blooded
animals,
SYNCAINE should be limited to hatchery or laboratory use. Avoid
inhaling or getting into
eyes.
Chemistry
SYNCAINE is the methanesulfonate of meta-amino benzoic acid
ethylester, or simply
ethyl m-amino benzoate. It is thus an isomer of benzocaine having the
formula
C9H11O2N + CH3SO3H
SYNCAINE is a fine white crystalline powder. Its molecular weight is
261.3. Soluble to
11%, it forms clear, colorless acid solutions in water.
TOXICOLOGY
Comparative toxicologic studies carried out on fish and frogs gave the
following results:
FISH TOXCITY STUDIES - The toxicity of SYNCAINE was measured by
standard methods
in laboratory bioassays with rainbow trout, brown trout, brook trout,
lake trout,
northern pike, channel catfish, bluegill, largemoth bass and walleye.
The 24, 48 and 96
hour LC50 (lethal concentration for 50 percent of the animals) values
for trout ranged
from 52 to 31 mg/liter; for northern pike, from 56 to 48 mg/liter; for
catfish, from 66 to
50 mg/liter; for bluegill and largemouth bass, from 61 to 39 mg/liter;
and for walleye, the
values were 49 to 46 mg/liter.
Safety Index:The safety indices for SYNCAINE refer to the ma