ROMPUN- xylazine injection, solution

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

XYLAZINE (UNII: 2KFG9TP5V8) (XYLAZINE - UNII:2KFG9TP5V8)

Dostupné s:

Elanco US Inc.

Podání:

INTRAMUSCULAR

Druh předpisu:

PRESCRIPTION

Terapeutické indikace:

Rompun® (xylazine injection) should be used in horses and Cervidae (Fallow Deer, Mule Deer, Sika Deer, White-Tailed Deer and Elk) when it is desirable to produce a state of sedation accompanied by a shorter period of analgesia. Horses: Rompun® (xylazine injection) has been used successfully as follows: - Diagnostic procedures–oral and ophthalmic examinations, abdominal palpation, rectal palpation, vaginal examination, catheterization of the bladder and radiographic examinations. - Orthopedic procedures, such as application of casting materials and splints. - Dental procedures. - Minor surgical procedures of short duration such as debridement, removal of cutaneous neoplasms and suturing of lacerations. - To calm and facilitate handling of fractious animals. - Therapeutic medication for sedation and relief of pain following injury or surgery. - Major surgical procedures: When used as a preanesthetic to general anesthesia. When used in conjunction with local anesthetics. - When used as a preanesthetic to gen

Přehled produktů:

Rompun® (xylazine injection) 100 mg/mL Injection for intravenous or intramuscular use is available in 50 mL multiple dose vials.

Stav Autorizace:

New Animal Drug Application

Charakteristika produktu

ROMPUN- XYLAZINE INJECTION, SOLUTION
ELANCO US INC.
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ROMPUN
(XYLAZINE INJECTION)
100 MG/ML
SEDATIVE AND ANALGESIC FOR USE IN HORSES AND CERVIDAE ONLY
DESCRIPTION:
Rompun (xylazine injection) is supplied in 50 mL multiple dose vials
as a sterile solution.
Each mL contains 100 mg Rompun (xylazine base equivalent); 0.9 mg
methylparaben;
0.1 mg propylparaben; water for injection; citric acid and sodium
citrate for pH
adjustment to 5.5 ± 0.3.
ACTIVE INGREDIENT:
xylazine hydrochloride
.................................................... 11.4%
(Equivalent to 10% base)
INERT INGREDIENTS:
88.6%
100.0%
CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the
order of a
licensed veterinarian. Do not use in Cervidae less than 15 days before
or during the
hunting season.
PHARMACOLOGY:
Rompun , a non-narcotic compound, is a sedative and analgesic as well
as muscle
relaxant. Its sedative and analgesic activity is related to central
nervous system
depression. Its muscle-relaxant effect is based on inhibition of the
intraneural
transmission of impulses in the central nervous system. The principal
pharmacological
activities develop within 10 to 15 minutes after intramuscular
injection, and within 3 to 5
minutes following intravenous administration in horses.
A sleeplike state, the depth of which is dose-dependent, is usually
maintained for 1 to 2
hours, while analgesia lasts from 15 to 30 minutes. The
centrally-acting muscle relaxant
effect causes relaxation of the skeletal musculature, complementing
sedation and
analgesia.
In horses and Cervidae under the influence of Rompun the respiratory
rate is reduced
as in natural sleep. Following treatment with Rompun the heart rate is
decreased and a
transient change in the conductivity of the cardiac muscle may occur,
as evidenced by a
partial atrioventricular block. This resembles the atrioventricular
block often observed in
®
®
®
®
®
®
1,2,3,4
normal horses.
Although a partial A-V block may occasionally occur following
intramuscular injection of Rompun (xy