OZVIR

Země: Austrálie

Jazyk: angličtina

Zdroj: Department of Health (Therapeutic Goods Administration)

Aktivní složka:

Aciclovir

Dostupné s:

Ranbaxy Australia Pty Ltd

Třída:

Medicine Registered

Informace pro uživatele

 
OZVIR CMI V3 Mar 2011 

OZVIR

ACICLOVIR 200 MG TABLETS 

CONSUMER MEDICINE INFORMATION 

WHAT IS IN THIS LEAFLET 

This leaflet answers some common questions
about OZVIR (aciclovir). 
It does not contain all the available information. 
It does not take the place of talking to your doctor or pharmacist. 
All medicines have risks and benefits. Your doctor has weighed the
risks of you taking this 
medicine against the benefits it is expected to have for you. 
IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR
OR PHARMACIST. 
Keep this leaflet with this medicine. You may need to read it again. 

WHAT OZVIR IS USED FOR 

OZVIR contains aciclovir, a compound that belongs to a group of
medicines called antivirals.  
OZVIR is used for the treatment of shingles (herpes zoster), impaired
immunity and genital herpes.  
In the case of shingles, OZVIR works by stopping the multiplication
of the virus which causes 
shingles. It can reduce the length and severity of an outbreak
of shingles but it will not get rid of the 
virus from your body. 
Aciclovir at high strength is used as part of the management
program in people who have human 
immunodeficiency virus disease (HIV). It acts by preventing further
damage to the immune system. 
In these people, OZVIR also guards against the herpes virus
disease. 
Aciclovir does not get rid of the virus from your body.   
Your doctor may have prescribed OZVIR for another purpose.  
OZVIR is not recommended for use in children as there have been no
studies of its effects in 
children
. 
ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY OZVIR HAS BEEN
PRESCRIBED FOR YOU.  
This medicine is only available with a doctor's prescription. 

OZVIR CMI V3 Mar 2011 
2

BEFORE YOU TAKE OZVIR 
_WHEN YOU MUST NOT TAKE IT_ 
DO NOT TAKE OZVIR IF:  
 
you have ever had an allergic reaction to OZVIR or to any of the
ingredients listed at the 
end of this

leaflet.  
Some of the sympto

Charakteristika produktu

 
_OZVIR (CLEAN) PI_V3_Aug 2011 _

1

PRODUCT INFORMATION 

NAME OF THE DRUG 

OZVIR TABLETS 

COMPOSITION - Active:  aciclovir 

CHEMICAL STRUCTURE: 

DESCRIPTION 

Synthetic acyclic purine nucleoside analogue.  Chemical name:
9-((2-hydroxyethoxy) methyl) 
guanine.  It is a white crystalline powder, slightly soluble in
water, freely soluble in dimethyl 
sulphoxide, very slightly soluble in alcohol. It dissolves in dilute
solutions of mineral acids and 
alkali hydroxides. CAS No.: 59277-89-3 

_Excipients_ – magnesium stearate, microcrystalline cellulose,
sodium starch glycollate, 
pregelatinised maize starch, colloidal anhydrous silica. 

PHARMACOLOGY 

ACTIONS – Antiviral agent. 

MICROBIOLOGY 

Aciclovir is an antiviral agent which is active in vitro
against _Herpes simples_ virus (HSV) types I 
and II and _Varicella zoster_ virus (VZV), the latter being
considerably less sensitive.  The 
relationship between the level of in vitro sensitivity of herpes
viruses to aciclovir and clinical 
response to therapy has not been adequately established.
 Development of resistance by HSV to 
aciclovir has been documented.  Aciclovir needs to be
phosphorylated to the active compound, 
aciclovir triphosphate, in order to become active against the virus.
 Such conversion is very 
limited in normal cells and, in addition, cellular DNA polymerase is
not very sensitive to the 
active compound.  However in infected cells, HSV or VZV coded
thymidine kinase facilitates 
the conversion of aciclovir to aciclovir monophosphate, which
is then converted to aciclovir 

_OZVIR (CLEAN) PI_V3_Aug 2011 _

2
triphosphate by cellular enzymes.  Aciclovir triphosphate acts as an
inhibitor of and substrate 
for the herpes specified DNA polymerase, preventing further viral
DNA synthesis. 

PHARMACOKINETICS_ _

Aciclovir is only partially and variably absorbed from the gut.
 Estimated bioavail