M.T.E.-4 CONCENTRATED SOLUTION

Země: Kanada

Jazyk: angličtina

Zdroj: Health Canada

Aktivní složka:

ZINC (ZINC SULFATE); COPPER (CUPRIC SULFATE); MANGANESE (MANGANESE SULFATE); CHROMIUM (CHROMIC CHLORIDE)

Dostupné s:

PHARMACEUTICAL PARTNERS OF CANADA INC

ATC kód:

B05XA30

INN (Mezinárodní Name):

COMBINATIONS OF ELECTROLYTES

Dávkování:

5MG; 1MG; 0.5MG; 10MCG

Léková forma:

SOLUTION

Složení:

ZINC (ZINC SULFATE) 5MG; COPPER (CUPRIC SULFATE) 1MG; MANGANESE (MANGANESE SULFATE) 0.5MG; CHROMIUM (CHROMIC CHLORIDE) 10MCG

Podání:

INTRAVENOUS

Jednotky v balení:

1/10ML

Druh předpisu:

Ethical

Terapeutické oblasti:

REPLACEMENT PREPARATIONS

Přehled produktů:

Active ingredient group (AIG) number: 0414689002; AHFS:

Stav Autorizace:

CANCELLED POST MARKET

Datum autorizace:

2008-02-15

Charakteristika produktu

PRODUCT MONOGRAPH
M.T.E.-4 AND M.T.E.-4 CONCENTRATED
_Multi-Trace Element _
Pharmaceutical Partners of Canada Inc.
Date of Preparation:
45 Vogell Road, Suite 200
January 15, 2008
Richmond Hill, ON
L4B 3P6
Control No.: 119203
1
NAME OF DRUG
M.T.E.-4 AND
M.T.E.-4 CONCENTRATED
THERAPEUTIC CLASSIFICATION
Multi-Trace Element
ACTIONS AND CLINICAL PHARMACOLOGY
ZINC
Zinc is an essential nutritional element that plays a key role as a
component of numerous metalloenzymes
such as carbonic anhydrase, alkaline phosphatase, lactic dehydrogenase
and carboxypeptidase. At least
one zinc metalloenzyme has been identified in each of the six major
categories of enzymes; i.e.,
oxidoreductase, transferase, hydrolase, lyase, isomerase and ligase.
Zinc is also necessary for the
synthesis of RNA and DNA, making it important in the normal growth and
development process. Zinc
helps maintain normal skin hydration and the senses of taste and smell
and facilitates wound healing.
Zinc resides in muscle, bone, skin, kidney, liver, pancreas, retina,
prostate and particularly in red and
white blood cells. Calculations from data indicate that 75 to 88% of
the total zinc of normal blood is
contained in red cells (primarily in the zinc metalloenzyme carbonic
anhydrase), 12 to 22% in the plasma
and 3% in the leukocytes. Normal plasma levels of zinc vary from
approximately 88 to 112 μg/100 mL.
Practically all zinc in serum is protein bound including plasma
albumin, α
2
-macroglobulin and some
plasma amino acids including histidine, cysteine, threonine, glycine
and asparagine. Infection influences
the uptake of zinc by the liver and reduces plasma concentration. This
process is stimulated by leukocyte
endogenous mediator (LEM).
Absorption of zinc occurs mainly in the small intestine, predominantly
in the duodenum. The primary
excretory pathway for zinc is the feces and pancreatic secretion. The
largest component comes from direct
transfer of zinc through the intestinal wall. Several researchers
showed that diarrhea, stomal and fistula
losses were maj