Liobac Tablet 10mg

Země: Malajsie

Jazyk: angličtina

Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

Aktivní složka:

BACLOFEN

Dostupné s:

Prestige Pharma Sdn Bhd

INN (Mezinárodní Name):

BACLOFEN

Jednotky v balení:

100Tablet Tablets; 200Tablet Tablets; 500Tablet Tablets; 50Tablet Tablets

Výrobce:

Sriprasit Pharma Co. Ltd.

Informace pro uživatele

_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_
LIOBAC TABLET
Baclofen (10 mg)
1
WHAT IS IN THE LEAFLET
1.
What LIOBAC is used for
2.
How LIOBAC works
3.
Before you use LIOBAC
4.
How to use LIOBAC
5.
While you are using it
6.
Side effects
7.
Storage and Disposal of LIOBAC
8.
Product Description
9.
Manufacturer and Product Registration
Holder
10.
Date of Revision
WHAT LIOBAC IS USED FOR
LIOBAC is used to reduce excess tension in
your
muscles
which
causes
spasms.
It
reduces spasms and the pain that happen in
various illnesses such as multiple sclerosis
and diseases or injuries of the spinal cord. It
helps to make you more mobile and better
able to manage your daily activities.
HOW LIOBAC WORKS
LIOBAC
contains
the
active
ingredient
Baclofen. It belongs to a group of medicines
called muscle relaxants. It works by restoring
the
normal
balance
and
reducing
muscle
hyperactivity. In this way, it allows for more
normal muscle movements.
BEFORE YOU USE LIOBAC
-
_When you must not use it_
Do not take this medicine if:
•
You
are
hypersensitive
to
the
active
ingredient
or
any
ingredients
in
the
formulation or any other similar medicines.
• You have peptic ulcer disease.
_If you are not sure whether you should start _
_taking this medicine, consult your doctor. _
-
_Before you start to use it _
Tell your doctor if you have allergies to any
other medicines, food, preservatives or dyes.
Tell your doctor if you have or have had any
medical conditions, especially:
• any psychiatric problems
• epilepsy and muscle spasticity
• peptic ulcers
• abnormal increase in muscle tone (sphincter
hypertonia)
• liver problems
• diabetes
If
you
are
pregnant,
intend
to
become
pregnant
or
nursing,
consult
your
doctor
before using this medicine.
-
_Taking other medicines _
Please tell your doctor or pharmacist if you
are
taking
any
other
medicines,
including
medicines obtained without a prescription,
herbal medicines or natural products.
Some
medicines
may
be
affected
by
LIOBAC, or may affect how well it works.
You may need to tak

Charakteristika produktu

CONTENT
Each plain tablet contains Baclofen 10 mg.
PRODUCT DESCRIPTION
White round tablet embossed with “SPS”, “L05” and a breakline
on one side
and plain on the other.
PROPERTIES
_PHARMACODYNAMICS _
Baclofen, an analogue of gamma-aminobutyric acid (GABA), is a
centrally
acting skeletal muscle relaxant. It inhibits monosynaptic and
polysynaptic
transmission at the spinal cord level by stimulating the GABA
β
receptors,
resulting in inhibition of the release of the excitatory amino acids
glutamate
and aspartate. Baclofen may act at supraspinal sites producing CNS
depression but has no effect on neuromuscular impulse transmission.
Baclofen also exerts an antinociceptive effect but the clinical
significance
of this is unknown.
_PHARMACOKINETICS _
_Absorption: _
Baclofen
is
rapidly
and
completely
absorbed
from
the
gastrointestinal
tract
following
an
oral
dose.
The
peak
plasma
concentration occurs in 0.5 to 3 hours following ingestion, but the
rate and
extent of absorption vary between patients, and vary inversely with
the
dose._ _
_Distribution: _
The
distribution
volume
of
baclofen
is
0.7
L/kg
and
approximately
30%
of
baclofen
is
bound
to
plasma
protein.
In
cerebrospinal
fluid,
the
active
substance
concentrations
are
approximately 8.5 times lower than in the plasma._ _
_Metabolism: _About 15% is metabolized in the liver to the
pharmacologically
inactive, β-(p-chlorophenyl)-4-hydroxybutyric acid._ _
_Elimination: _The plasma elimination half-life of baclofen is about 3
– 4 hours.
About 75% of the dose is excreted via the kidney within 72 hours,
mainly as
unchanged drug. The remainder of the dose, including 5% in the form of
metabolites, is excreted in faeces._ _
INDICATION
LIOBAC is indicated for the alleviation of spasticity of the skeletal
muscles in
multiple sclerosis and other spastic conditions occurring from spinal
cord
diseases of infectious, degenerative, traumatic, neoplastic or unknown
origin
(e.g.
spastic
spinal
paralysis,
amyotrophic
lateral
sclerosis,
syringomyelia, transverse myelitis, trauma