Země: Malajsie
Jazyk: angličtina
Zdroj: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE
MERCK SHARP & DOHME (MALAYSIA) SDN BHD
METFORMIN HYDROCHLORIDE; SITAGLIPTIN PHOSPHATE
56Tablet Tablets; 28Tablet Tablets; 14Tablet Tablets
Patheon Puerto Rico, Inc.
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ JANUMET ® TABLET _ _ Sitagliptin phosphate/metformin hydrochloride (50 mg/500 mg, 50 mg/850 mg, 50mg/1000 mg) 1 WHAT IS IN THIS LEAFLET 1. What JANUMET is used for 2. How JANUMET works 3. Before you use JANUMET 4. How to use JANUMET 5. While you are using JANUMET 6. Side effects 7. Storage and Disposal of JANUMET 8. Product description 9. Manufacturer and Product Registration Holder 10. Date of Revision WHAT JANUMET IS USED FOR JANUMET is a tablet that contains two prescription medicines, sitagliptin phosphate (JANUVIA ® ) and metformin, which lower blood sugar. Sitagliptin, a member of a class of medicines called DPP-4 inhibitors (dipeptidyl peptidase-4 inhibitors), and metformin, a member of the biguanide class of medicines, work together to control blood sugar levels in patients with type 2 diabetes mellitus. Type 2 diabetes is also called non-insulin-dependent diabetes mellitus, or NIDDM. WHY HAS MY DOCTOR PRESCRIBED JANUMET? Your doctor has prescribed JANUMET, along with diet and exercise, to help lower your blood sugar. WHAT IS TYPE 2 DIABETES? Type 2 diabetes is a condition in which your body does not make enough insulin, and the insulin that your body produces does not work as well as it should. Your body can also make too much sugar. When this happens, sugar builds up in the blood. This can lead to serious medical problems. The main goal of treating diabetes is to lower your blood sugar to a normal level. Lowering and controlling blood sugar may help prevent or delay complications of diabetes, such as heart problems, kidney problems, blindness, and amputation. High blood sugar can be lowered by diet and exercise, and by certain medicines. HOW CAN I LEARN MORE ABOUT JANUMET AND DIABETES? You may obtain further information from your doctor or pharmacist, who has more detailed information. HOW JANUMET WORKS JANUMET lowers blood sugar levels in patients with type 2 diabetes. JANUMET helps to improve the levels of insulin after a meal. JANUMET he Přečtěte si celý dokument
All rights reserved. LOCAL PRODUCT CIRCULAR LPC-MK0431A-T-052020 JANUMET® (sitagliptin phosphate/metformin HCl) Tablets I. THERAPEUTIC CLASS JANUMET JANUMET (sitagliptin phosphate/metformin HCl) combines two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes: sitagliptin phosphate, a dipeptidyl peptidase 4 (DPP-4) inhibitor, and metformin hydrochloride, a member of the biguanide class. Sitagliptin phosphate Sitagliptin phosphate is an orally-active, potent, and highly selective inhibitor of the dipeptidyl peptidase 4 (DPP-4) enzyme for the treatment of type 2 diabetes. The DPP-4 inhibitors are a class of agents that act as incretin enhancers. By inhibiting the DPP-4 enzyme, sitagliptin increases the levels of two known active incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The incretins are part of an endogenous system involved in the physiologic regulation of glucose homeostasis. When blood glucose concentrations are normal or elevated, GLP-1 and GIP increase insulin synthesis and release from pancreatic beta cells. GLP-1 also lowers glucagon secretion from pancreatic alpha cells, leading to reduced hepatic glucose production. This mechanism is unlike the mechanism seen with sulfonylureas; sulfonylureas cause insulin release even when glucose levels are low, which can lead to sulfonylurea-induced hypoglycemia in patients with type 2 05KL97 diabetes and in normal subjects. Sitagliptin is a potent and highly selective inhibitor of the enzyme DPP-4 and does not inhibit the closely-related enzymes DPP-8 or DPP-9 at therapeutic concentrations. Sitagliptin differs in chemical structure and pharmacological action from GLP-1 analogues, insulin, sulfonylureas or meglitinides, biguanides, peroxisome proliferator-activated receptor gamma (PPARγ ) agonists, alpha- glucosidase inhibitors, and amylin analogues. Metformin hydrochloride Metformin is an antihyperglycemic agent which improves glu Přečtěte si celý dokument