Země: Spojené státy
Jazyk: angličtina
Zdroj: NLM (National Library of Medicine)
ISOFLURANE (UNII: CYS9AKD70P) (ISOFLURANE - UNII:CYS9AKD70P)
Henry Schein Animal Health
ISOFLURANE
ISOFLURANE 1 mL in 1 mL
PRESCRIPTION
Abbreviated New Animal Drug Application
ISOTHESIA- ISOFLURANE INHALANT HENRY SCHEIN ANIMAL HEALTH ---------- 03-A926/R5 5260-04-04 AND 5260-04-09 ISOTHESIA™ (ISOFLURANE, USP) WARNING: NOT FOR USE IN HORSES INTENDED FOR FOOD. INHALATION ANESTHETIC FOR USE IN HORSES AND DOGS CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian. DESCRIPTION ISOTHESIA (isoflurane, USP) is a nonflammable, nonexplosive general inhalation anesthetic agent. Its chemical name is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is: Each mL contains 99.9% isoflurane. Isoflurane is a clear, colorless, stable liquid containing no additives or chemical stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor. Samples stored in indirect sunlight in clear, colorless glass for five years, as well as samples directly exposed for 30 hours to a 2 amp,115 volt, 60 cycle long wave U.V. light were unchanged in composition as determined by gas chromatography. Isoflurane in one normal sodium methoxide-methanol solution, a strong base, for over six months consumed essentially no alkali, indicative of strong base stability. Isoflurane does not decompose in the presence of soda lime (at normal operating temperatures) and does not attack aluminum, tin, brass, iron or copper. CLINICAL PHARMACOLOGY ISOTHESIA (isoflurane, USP) is an inhalation anesthetic. Induction and recovery from anesthesia with isoflurane are rapid. The level of anesthesia may be changed rapidly with isoflurane. Isoflurane is a profound respiratory depressant. RESPIRATION MUST BE MONITORED CLOSELY IN THE HORSE AND DOG AND SUPPORTED WHEN NECESSARY. As anesthetic dose is increased, both 2,5 3,6 tidal volume and respiratory rate decrease. This depression is partially reversed by surgical stimulation, even at deeper levels of anesthesia. Blood pressure decreases with induction of anesthesia but returns toward normal with surgical stimulation. Progressive increases in depth of anesthesia produce corresponding decreases in blood pressure; however, heart Přečtěte si celý dokument