ISOSOL- isoflurane liquid

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

ISOFLURANE (UNII: CYS9AKD70P) (ISOFLURANE - UNII:CYS9AKD70P)

Dostupné s:

Vedco, Inc.

INN (Mezinárodní Name):

ISOFLURANE

Složení:

ISOFLURANE 1 mL in 1 mL

Podání:

RESPIRATORY (INHALATION)

Druh předpisu:

PRESCRIPTION

Terapeutické indikace:

Isoflurane, USP is used for induction and maintenance of general anesthesia in horses and dogs. Isoflurane, USP is contraindicated in horses and dogs with known sensitivity to isoflurane or to other halogenated agents.

Přehled produktů:

Isoflurane, USP is packaged in 100 mL (NDC 50989-150-12) and 250 mL (NDC 50989-150-15) amber-colored bottles. Store at room temperature 20º to 25ºC (68º to 77ºF); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].

Stav Autorizace:

Abbreviated New Animal Drug Application

Charakteristika produktu

ISOSOL - ISOFLURANE LIQUID
VEDCO, INC.
----------
WARNING: NOT FOR USE IN HORSES INTENDED FOR FOOD.
ISOSOL™
ISOFLURANE USP
INHALATION ANESTHETIC
FOR VETERINARY USE IN HORSE AND DOGS
CAUTION
Federal law restricts this drug to use by or on the order of a
licensed veterinarian.
DESCRIPTION
Isoflurane, USP is a nonflammable, nonexplosive general inhalation
anesthetic agent. Its
chemical name is l-chloro-2,2,2-trifluoroethyl difluoromethyl ether,
and its structural
formula is:
Each mL contains 99.9% isoflurane.
Some physical constants are:
Molecular weight
184.5
Boiling point at 760 mm Hg
48.5° C (uncorr.)
Refractive index n
1.2990-1.3005
Specific gravity 25°/25° C
1.496
Vapor pressure in mm Hg** 20° C
238
25° C
295
30° C
367
35° C
450
**Equation for vapor pressure calculation:
log
_P_
= A + B
T where: A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)
Partition coefficients at 37°
20
D
10_ vap_
C:
Water/gas
0.61
Blood/gas
1.43
Oil/gas
90.8
Partition coefficients at 25° C - rubber and plastic
Conductive rubber/gas
62.0
Butyl rubber/gas
75.0
Polyvinyl chloride/gas
110.0
Polyethylene/gas
~2.0
Polyurethane/gas
~1.4
Polyolefin/gas
~1.1
Butyl acetate/gas
~2.5
Purity by gas chromatography
>99.9%
Lower limit of flammability in oxygen or
nitrous oxide at 9 joules/sec. and 23° C
None
Lower limit of flammability in oxygen or nitrous oxide
at 900 joules/sec. and 23° C
Greater than useful concentration in anesthesia.
MAC (Minimum Alveolar Concentration) is 1.31% in horses and 1.28% in
dogs.
Isoflurane is a clear, colorless, stable liquid containing no
additives or chemical
stabilizers. Isoflurane has a mildly pungent, musty, ethereal odor.
Samples stored in
indirect sunlight in clear, colorless glass for five years, as well as
samples directly
exposed for 30 hours to a 2 amp, 115 volt, 60 cycle long wave U.V.
light were
unchanged in composition as determined by gas chromatography.
Isoflurane in one
normal sodium methoxide-methanol solution, a strong base, for over six
months
consumed essentially no alkali, indicative o