Země: Spojené státy
Jazyk: angličtina
Zdroj: NLM (National Library of Medicine)
EXAMETAZIME (UNII: G29272NCKL) (EXAMETAZIME - UNII:G29272NCKL)
AnazaoHealth Corporation
EXAMETAZIME
EXAMETAZIME 1 mg
INTRAVENOUS
PRESCRIPTION DRUG
Exametazime is a diagnostic agent used as an adjunct in the detection of altered cerebral perfusion in stroke patients and is also indicated for white blood cell labeling as an adjunct in the localization of abdominal infections and inflammatory bowel disease There are no known contraindications for this preparation.
unapproved drug other
EXAMETAZIME HMPAO- EXAMETAZIME INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION ANAZAOHEALTH CORPORATION _Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been_ _approved by FDA. For further information about unapproved drugs, click here._ ---------- EXAMETAZIME (HMPAO) (FOR THE PREPARATION OF TC99M EXAMETAZIME INJECTION) Dear Medical Professional, Per your order, we have compounded Exametazime as a sterile, freeze-dried preparation in a 10 mL vial. The characteristics of this preparation are described below DESCRIPTION AnazaoHealth’s compounded Exametazime vial is a sterile, non-pyrogenic preparation that consists of a lyophilized mixture of 1 mg of Exametazime, 6.75 mg of Sodium Chloride, 11.4 µg of Stannous Chloride Dihydrate and is maintained under an inert nitrogen atmosphere. The kit also contains a vial of Cobalt Chloride, which contains 0.3 mg of cobalt chloride hexahydrate, or Methylene Blue 1% (methylene blue 10 mg/mL) and Phosphate Buffer (monobasic sodium phosphate, sodium chloride, dibasic sodium phosphate This kit contains no antimicrobial preservative CLINICAL PHARMACOLOGY CEREBRAL SCINTIGRAPHY When Exametazime is reconstituted with Tc99m pertechnetate, a lipophilic complex of Tc99m Exametazime is formed and is the active ingredient of the reconstituted product. The lipophilic complex crosses the blood-brain barrier. It converts to the less lipophilic complex 12% per hour. The preparation is good for 30 minutes without the use of a stabilizer. The _in vitro_ addition of cobalt chloride helps to stabilize the complex for 6 hours. LEUKOCYTE (WBC) LABELING The lipophilic complex of Tc99m Exametazime is taken up by leukocytes and selectively retained by neutrophils. Cobalt chloride, as a stabilizer, may be used with this procedure as well INDICATIONS AND USAGE Exametazime is a diagnostic agent used as an adjunct in the detection of altered cerebral perfusion in stroke patients and is also indicated for white blood cell labeling as an adjunct in the loca Přečtěte si celý dokument