EPINEPHRINE- epinephrine injection

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

Epinephrine (UNII: YKH834O4BH) (Epinephrine - UNII:YKH834O4BH)

Dostupné s:

International Medication Systems, Limited

INN (Mezinárodní Name):

Epinephrine

Složení:

Epinephrine 0.1 mg in 1 mL

Podání:

INTRAVENOUS

Druh předpisu:

PRESCRIPTION DRUG

Terapeutické indikace:

EPINEPHRINE Epinephrine’s cardiac effects may be of use in the treatment and prophylaxis of cardiac arrest due to various causes in the absence of ventricular fibrillation and attacks of transitory atrioventricular (AV) heart block with syncopal seizures (Stokes-Adams syndrome), but it is not used in cardiac failure or in hemorrhagic, traumatic or in cardiogenic shock. Epinephrine may be used to stimulate the heart in syncope due to complete heart block or carotid sinus hypersensitivity. Epinephrine is also used for resuscitation in cardiac arrest following anesthetic accidents. In cardiopulmonary resuscitation, intracardiac puncture and intramyocardial injection of epinephrine may be effective when external cardiac compression and attempts to restore the circulation by electrical defibillation or use of a pacemaker fail. Epinephrine is seldom used as a vasopressor except in the treatment of anaphylactic shock and under certain conditions in insulin shock. Epinephrine should not be used in the presence of car

Přehled produktů:

EPINEPHRINE INJECTION, USP, 0.1 mg/ mL In unit-use packages containing a Luer-Jet™  Luer-Lock Prefilled Syringe Ten cartons per package. Syringe Assembly Directions: USE ASEPTIC TECHNIQUE Do not assemble until ready to use. *CAUTION: IMPROPER ENGAGING MAY CAUSE GLASS BREAKAGE AND SUBSEQUENT INJURY. Protect the solution from light, extreme heat and freezing. Store at controlled room temperature 15˚ to 30˚C (59˚ to 86˚F). NOTE: Do not use the injection if its color is pinkish or darker than slightly yellow or if it contains a precipitate. Rx Only

Stav Autorizace:

unapproved drug other

Charakteristika produktu

EPINEPHRINE - EPINEPHRINE INJECTION
INTERNATIONAL MEDICATION SYSTEMS, LIMITED
_Disclaimer: This drug has not been found by FDA to be safe and
effective, and this_
_labeling has not been approved by FDA. For further information about
unapproved_
_drugs, click here._
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EPINEPHRINE INJECTION, USP
AVAILABLE AS:
EPINEPHRINE INJECTION, USP, 0.1 MG/ML
FOR INTRACARDIAC OR
INTRAVENOUS USE
DESCRIPTION
Epinephrine is the active principle of the adrenal medulla. Chemically
described as (-)-3,4-
Dihydroxy-α-[(methyl-amino) methyl] benzyl alcohol, it has the
following structural
formula:
Epinephrine is a sterile aqueous solution of epinephrine prepared with
the aid of
hydrochloric acid. Each mL of the solution contains 0.1 mg epinephrine
and 1 mg
sodium bisulfite. Sodium bisulfite is an antioxidant. This solution
also contains sodium
chloride for adjustment of tonicity, and 10% w/v hydrochloric acid to
dissolve
epinephrine and to adjust pH to meet USP limits of 2.2 to 5.0.
Additionally, the solution
also contains sodium citrate and citric acid as buffers for
stabilization. The air above the
liquid in the individual containers have been displaced by flushing
with nitrogen during
the filling operation. No antimicrobial preservatives have been added
and each vial is
intended as a single dose; once the unit is assembled and used, any
remaining portion of
the solution must be discarded with the entire unit.
CLINICAL PHARMACOLOGY
The actions of epinephrine resemble the effects of stimulation of
adrenergic nerves. To a
variable degree, it acts on both alpha and beta receptor sites of
sympathetic effector
cells. Its most prominent actions are on the beta receptors of the
heart, vascular and
other smooth muscle. When given by rapid I.V. injection it produces a
rapid rise in blood
pressure, mainly systolic, direct stimulation of cardiac muscle which
increases the
strength of ventricular contraction, increases the heart rate, and
constricts the
arterioles in the skin, mucosa and splanchnic areas of circulation.
Epinephrine rela