E-SE- sodium selenite and .alpha.-tocopherol acetate, d- injection, solution

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

sodium selenite (UNII: HIW548RQ3W) (SELENITE ION - UNII:KXO0259XJ1), .ALPHA.-TOCOPHEROL ACETATE, D- (UNII: A7E6112E4N) (.ALPHA.-TOCOPHEROL, D- - UNII:N9PR3490H9)

Dostupné s:

Merck Sharp & Dohme Corp.

Podání:

INTRAVENOUS

Druh předpisu:

PRESCRIPTION

Terapeutické indikace:

INDICATIONS E-SE Injection is recommended for the control of the following clinical signs when associated with myositis (Selenium-Tocopherol Deficiency) syndrome: rapid respiration, profuse sweating, muscle spasms and stiffness, elevated SGOT.

Přehled produktů:

HOW SUPPLIED 100 mL sterile, multiple-dose glass vial, NDC 0061-0709-04. STORAGE Store between 2 and 30 C (36 and 86 F). Protect from freezing.

Stav Autorizace:

New Animal Drug Application

Charakteristika produktu

E-SE- SODIUM SELENITE AND .ALPHA.-TOCOPHEROL ACETATE, D- INJECTION,
SOLUTION
MERCK SHARP & DOHME CORP.
----------
E-SE
(SELENIUM, VITAMIN E)
INJECTION
FOR VETERINARY USE ONLY
Approved by FDA under NADA # 030-315
PRODUCT INFORMATION
CAUTION Federal law restricts this drug to use by or on the order of a
licensed
veterinarian.
DESCRIPTION E-SE Injection is an emulsion of selenium-tocopherol for
the prevention
and treatment of myositis (Selenium-Tocopherol Deficiency) syndrome in
horses. EACH
ML CONTAINS: 5.48 mg sodium selenite (equivalent to 2.5 mg selenium),
50 mg (68 USP
units or IU) vitamin E (as _d_-alpha tocopheryl acetate), 250 mg
polyoxyethylated
vegetable oil, 2% benzyl alcohol (preservative), water for injection
q.s. Sodium hydroxide
and/or hydrochloric acid may be added to adjust pH.
PHARMACOLOGY It has been demonstrated that selenium and tocopherol
exert
physiological effects and that these effects are intertwined with
sulfur metabolism.
Additionally, tocopherol appears to have a significant role in the
oxidation process, thus
suggesting an interrelationship between selenium and tocopherol in
overcoming sulfur-
induced depletion and restoring normal metabolism. Although oral
ingestion of adequate
amounts of selenium and tocopherol would seemingly restore normal
metabolism, it is
apparent that the presence of sulfur and, perhaps, other factors
interfere during the
digestive process with proper utilization of selenium and tocopherol.
When selenium and
tocopherol are injected, they bypass the digestive process and exert
their full metabolic
effects promptly on cell metabolism. Anti-inflammatory action has been
demonstrated
by selenium-tocopherol in the Selye Pouch Technique and experimentally
induced
polyarthritis study in rats.
INDICATIONS E-SE Injection is recommended for the control of the
following clinical
signs when associated with myositis (Selenium-Tocopherol Deficiency)
syndrome: rapid
respiration, profuse sweating, muscle spasms and stiffness, elevated
SGOT.
CAUTION Intravenous administration, if