CHLOROQUINE phosphate tablet

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

CHLOROQUINE PHOSPHATE (UNII: 6E17K3343P) (CHLOROQUINE - UNII:886U3H6UFF)

Dostupné s:

Golden State Medical Supply, Inc.

INN (Mezinárodní Name):

CHLOROQUINE PHOSPHATE

Složení:

CHLOROQUINE PHOSPHATE 250 mg

Druh předpisu:

PRESCRIPTION DRUG

Stav Autorizace:

Abbreviated New Drug Application

Charakteristika produktu

CHLOROQUINE- CHLOROQUINE PHOSPHATE TABLET
CHLOROQUINE- CHLOROQUINE PHOSPHATE TABLET, COATED
GOLDEN STATE MEDICAL SUPPLY, INC.
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CHLOROQUINE PHOSPHATE
TABLETS, USP
250 MG AND 500 MG
Rev. 05/10
RX ONLY
FOR MALARIA AND EXTRAINTESTINAL AMEBIASIS
DESCRIPTION
Chloroquine Phosphate, USP, is a 4-aminoquinoline compound for oral
administration. It is a white,
odorless, bitter tasting, crystalline substance, freely soluble in
water.
Chloroquine Phosphate Tablets are an antimalarial and amebicidal drug.
Each tablet, for oral administration, contains 250 mg chloroquine
phosphate (equivalent to 150 mg base)
or 500 mg chloroquine phosphate (equivalent to 300 mg base).
Inactive ingredients 250 mg: Calcium Stearate, Colloidal Silicon
Dioxide, Dibasic Calcium Phosphate,
Microcrystalline Cellulose, and Talc.
Inactive ingredients 500 mg: Colloidal Silicon Dioxide, Corn Starch,
Lactose Monohydrate, Magnesium
Stearate, Microcrystalline Cellulose, Polyvinylpyrrolidone, Sodium
Starch Glycolate, and Titanium
Dioxide. Film Coating and Polishing Solution contains: D&C Red #27
Aluminum Lake, D&C Yellow
#10 Aluminum Lake, FD&C Blue #1 Aluminum Lake, Hypromellose,
Polyethylene Glycol, Polysorbate
80 and Titanium Dioxide.
Chemically, it is 7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]
quinoline phosphate (1:2) and has
the following structural formula:
CLINICAL PHARMACOLOGY
Chloroquine is rapidly and almost completely absorbed from the
gastrointestinal tract, and only a small
proportion of the administered dose is found in the stools.
Approximately 55% of the drug in the plasma
is bound to nondiffusible plasma constituents. Excretion of
chloroquine is quite slow, but is increased
by acidification of the urine. Chloroquine is deposited in the tissues
in considerable amounts. In
animals, from 200 to 700 times the plasma concentration may be found
in the liver, spleen, kidney, and
lung; leukocytes also concentrate the drug. The brain and spinal cord,
in contrast, contain only 10 to 30
times the amount present in plasma.
Chloroquine