Cafergot

Země: Austrálie

Jazyk: angličtina

Zdroj: Department of Health (Therapeutic Goods Administration)

Aktivní složka:

Ergotamine tartrate; Caffeine

Dostupné s:

Novartis Pharmaceuticals Australia Pty Ltd

Třída:

Medicine Registered

Informace pro uživatele

CAFERGOT(R)
1
CAFERGOT(R)
_ergotamine tartrate/caffeine_
CONSUMER MEDICINE INFORMATION
WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about Cafergot tablets and
Cafergot S suppositories.
It does not contain all the available
information. It does not take the
place of talking to your doctor and
pharmacist.
The information in this leaflet was
last updated on the date listed on the
final page. More recent information
on the medicine may be available.
YOU SHOULD ENSURE THAT YOU SPEAK
TO YOUR PHARMACIST OR DOCTOR TO
OBTAIN THE MOST UP TO DATE
INFORMATION ON THE MEDICINE. YOU
CAN ALSO DOWNLOAD THE MOST UP TO
DATE LEAFLET FROM
WWW.NOVARTIS.COM.AU.
Those updates may contain important
information about the medicine and
its use of which you should be aware.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you using Cafergot
against the benefits it can provide.
IF YOU HAVE ANY CONCERNS ABOUT THIS
MEDICINE, ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT CAFERGOT IS USED
FOR
Cafergot is used to treat attacks of
migraine and other similar "vascular"
headaches.
These headaches are thought to be
caused by temporary changes in the
size of small blood vessels in the
brain. These blood vessels swell,
causing the pain and visual
disturbances that often happen
during an attack. Cafergot stops the
attack by causing the blood vessels to
constrict (shrink) back to normal
size.
Cafergot is only used to treat
migraine attacks. It is not used to
prevent attacks from happening.
There are some types of headaches
which must not be treated with
Cafergot. Your doctor will
determine the best treatment for your
headache.
Cafergot tablets and Cafergot S
suppositories contain the active
ingredients, ergotamine tartrate and
caffeine. Ergotamine belongs to a
group of medicines known as the
"ergot alkaloids." Caffeine helps
ergotamine

Charakteristika produktu

1 

CAFERGOT
®

NAME OF THE MEDICINE 

Active ingredient 

Ergotamine tartrate 

Caffeine 
Chemical name  bis [(6a_R_,9_R_)-_N_-[(2_R_,5_S_,10a_S_,10b_S_)-5-
benzyl-10b-hydroxy-2-methyl-3,6-dioxo-
octahydro-8_H_-oxazolo [3,2-a] pyrrolo 
[2,1-c] pyrazin-2-yl]-7-methyl-
4,6,6a,7,8,9-hexahydroindolo [4,3-_fg_] 
quinoline-9-carboxamide] tartrate 
1,3,7-Trimethyl-3,7-
dihydro-1_H_-purine-2,6-
dione 
CAS number  379-79-3 
58-08-2 
Molecular weight  1313   
194.2     
Molecular formula  (C
33
H
35
N
5
O
5
)
2
,C
4
H
6
O
6

C
8
H
10
N
4
O
2

Chemical structure 

DESCRIPTION 

Ergotamine tartrate is a
slightly hygroscopic colourless, odourless crystal or white or 
yellowish-white crystalline powder.  It is soluble in water,
slightly soluble in ethanol and 
chloroform and practically insoluble in ether. 

Caffeine is an odourless, silky white crystal, or white crystalline powder which sublimes 
readily. It is sparingly soluble in water and
is slightly soluble in alcohol and ether. 

TABLETS 
Cafergot
®
  tablets contain ergotamine tartrate 1 mg and caffeine
100 mg. Cafergot tablets are 
white, round sugar coated, tablets with no markings.  

SUPPOSITORIES  
Cafergot
®
  S suppositories contain ergotamine tartrate 2 mg and
caffeine 100 mg. Cafergot S 
suppositories are whitish or with  a tinge of grey/pink,
approximately 30 mm in length and 
approximately 10 mm thick. 

2 

PHARMACOLOGY 
Pharmacotherapeutic group: antimigraine preparations 
ATC code: NO2C A52 

MECHANISM OF ACTION 
The mode of action
of ergotamine in aborting attacks of migraine and other vascular headaches 
may be due to its direct vasoconstrictive
action on the dilated extracranial arteries.  Caffeine 
accelerates and increases the
enteral absorption of ergotamine. 

PHARMACOKINETICS 
ERGOTAMINE  
Absorption 
T