Země: Jihoafrická republika
Jazyk: angličtina
Zdroj: South African Health Products Regulatory Authority (SAHPRA)
Adcock
ADCO-CEFACLOR BD TABLETS 375 mg SCHEDULING STATUS : S4 PROPRIETARY NAME (and dosage form): ADCO-CEFACLOR BD TABLETS 375 mg COMPOSITION: Each ADCO-CEFACLOR BD TABLET 375 mg (convenient dose) contains 375 mg cefaclor . Cefaclor is chemically 3-chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid monohydrate. PHARMACOLOGICAL CLASSIFICATION: A 20.1.1 Broad and Medium Spectrum Antibiotics PHARMACOLOGICAL ACTION: ADCO-CEFACLOR BD TABLETS 375 mg is a pharmaceutically-modified form of the orally active cephalosporin, cefaclor. It is a semi-synthetic cephalosporin antibiotic for oral administration. Human pharmacology: ADCO-CEFACLOR BD TABLETS 375 mg differs from cefaclor in its rate of dissolution, producing a lower peak serum concentration, but retaining sustained measurable serum concentrations, which provides the advantage of twice daily dosing. ADCO-CEFACLOR BD TABLETS 375 mg is well absorbed from the gastro-intestinal tract after oral administration. Although ADCO-CEFACLOR BD TABLETS 375 mg can be taken with or without food, absorption is enhanced with food. When it was given within 1 hour after a meal, the bioavailability of ADCO-CEFACLOR BD TABLETS 375 mg was greater than 90%, using cefaclor as a reference. When taken in the fasting state, the bioavailability of ADCO- CEFACLOR BD TABLETS 375 mg was 77% that of cefaclor. Compared to cefaclor (fasted state), mean peak plasma concentrations of ADCO-CEFACLOR BD TABLETS 375 mg (both fed and fasted states) were delayed by 40 to 90 minutes and were approximately 25% lower. Concomitant administration of H 2 blockers does not affect the rate or extent of absorption. Administration of magnesium- or aluminium hydroxide-containing antacids 1 hour after ADCO- CEFACLOR BD TABLETS 375 mg had no effect on the rate of absorption, but Přečtěte si celý dokument