ACYCLOVIR capsule

Země: Spojené státy

Jazyk: angličtina

Zdroj: NLM (National Library of Medicine)

Aktivní složka:

ACYCLOVIR (UNII: X4HES1O11F) (ACYCLOVIR - UNII:X4HES1O11F)

Dostupné s:

Quinn Pharmaceuticals

INN (Mezinárodní Name):

Acyclovir

Složení:

Acyclovir 200 mg

Podání:

ORAL

Druh předpisu:

PRESCRIPTION DRUG

Terapeutické indikace:

Acyclovir is contraindicated for patients who develop hypersensitivity to acyclovir or valacyclovir.

Přehled produktů:

Acyclovir Capsules USP, 200 mg Oval capsule, light blue opaque cap and aqua blue opaque body imprinted with “QP146” are supplied in bottles of 100 (NDC 69076-146-01)

Stav Autorizace:

Abbreviated New Drug Application

Charakteristika produktu

ACYCLOVIR- ACYCLOVIR CAPSULE
QUINN PHARMACEUTICALS
----------
ACYCLOVIR CAPSULES USP
DESCRIPTION
Acyclovir is a synthetic nucleoside analogue active against herpes
viruses. Acyclovir
capsules are formulations for oral administration.
Each capsule contains 200 mg of acyclovir and the inactive
ingredients: lactose
monohydrate, sodium lauryl sulfate, sodium starch glycolate, and
magnesium stearate.
The capsule shell consists of FD&C Blue #1, gelatin, and titanium
dioxide. The imprinting
ink contains, FD&C Blue #1, FD&C Blue #2, FD&C Red #40, D&C Yellow
#10, iron oxide
black, pharmaceutical shellac glaze and propylene glycol.
Acyclovir is a white, crystalline powder with the molecular formula C
H
N
O
and a
molecular weight of 225. The maximum solubility in water at 37degree C
is 2.5 mg/mL.
The pka's of acyclovir are 2.27 and 9.25.
The chemical name of acyclovir is
2-amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6
_H_-purin-6-one; it has the following structural formula:
VIROLOGY
MECHANISM OF ANTIVIRAL ACTION:
Acyclovir is a synthetic purine nucleoside analogue with _in vitro
_and _in vivo _inhibitory
activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and
varicella-zoster
virus (VZV). The inhibitory activity of acyclovir is highly selective
due to its affinity for the
enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme
converts
acyclovir into acyclovir monophosphate, a nucleotide analogue. The
monophosphate is
further converted into diphosphate by cellular guanylate kinase and
into triphosphate by
a number of cellular enzymes. _In vitro_, acyclovir triphosphate stops
replication of herpes
viral DNA. This is accomplished in 3 ways: 1) competitive inhibition
of viral DNA
polymerase, 2) incorporation into and termination of the growing viral
DNA chain, and 3)
inactivation of the viral DNA polymerase. The greater antiviral
activity of acyclovir against
HSV compared to VZV is due to its more efficient phosphorylation by
the viral TK.
8
11
5
3
ANTIVIRAL ACTIVITIES:
The quantitative relation