País: Singapur
Idioma: anglès
Font: HSA (Health Sciences Authority)
SIMVASTATIN
ORGANON SINGAPORE PTE. LTD.
C10AA01
10.0 mg
TABLET, FILM COATED
SIMVASTATIN 10.0 mg
ORAL
Prescription Only
Organon Pharma (UK) Limited
ACTIVE
1990-02-01
ZOCOR PAGE 1 OF 11 SG-MK0733-T-072014 (SIMVASTATIN) PHYSICIANS CIRCULAR Tablets Trademark ZOCOR® (simvastatin) ZOCOR (simvastatin) is a lipid-lowering agent derived synthetically from a fermentation product of _Aspergillus terreus_. After oral ingestion, ZOCOR, an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes an early and rate-limiting step in the biosynthesis of cholesterol. Clinical studies show ZOCOR to be highly effective in reducing total plasma cholesterol (total-C), low- density lipoprotein cholesterol (LDL-C), triglycerides (TG), and very-low-density lipoprotein cholesterol (VLDL-C) concentrations, and increasing high-density lipoprotein cholesterol (HDL-C) in heterozygous familial and non-familial forms of hypercholesterolemia, and in mixed hyperlipidemia when elevated cholesterol was cause for concern and diet alone has been insufficient. Marked responses are seen within 2 weeks, and maximum therapeutic responses occur within 4-6 weeks. The response is maintained during continuation of therapy. When therapy with ZOCOR is stopped, cholesterol and lipids return to pretreatment levels. The active form of simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate. Because the conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway of cholesterol, therapy with ZOCOR would not be expected to cause an accumulation of potentially toxic sterols. In addition, HMG-CoA is also metabolized readily back to acetyl Llegiu el document complet
ZOCOR SG-OG0733-T-052023 (simvastatin) PHYSICIANS CIRCULAR Tablets Trademark ZOCORⓇ (simvastatin) ZOCOR (simvastatin) is a lipid-lowering agent derived synthetically from a fermentation product of Aspergillus terreus . After oral ingestion, ZOCOR, an inactive lactone, is hydrolyzed to the corresponding β-hydroxyacid form. This is a principal metabolite and an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes an early and rate-limiting step in the biosynthesis of cholesterol. Clinical studies show ZOCOR to be highly effective in reducing total plasma cholesterol (total-C), low- density lipoprotein cholesterol (LDL-C), triglycerides (TG), and very-low-density lipoprotein cholesterol (VLDL-C) concentrations, and increasing high-density lipoprotein cholesterol (HDL-C) in heterozygous familial and non-familial forms of hypercholesterolemia, and in mixed hyperlipidemia when elevated cholesterol was cause for concern and diet alone has been insufficient. Marked responses are seen within 2 weeks, and maximum therapeutic responses occur within 4-6 weeks. The response is maintained during continuation of therapy. When therapy with ZOCOR is stopped, cholesterol and lipids return to pretreatment levels. The active form of simvastatin is a specific inhibitor of HMG-CoA reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate. Because the conversion of HMG-CoA to mevalonate is an early step in the biosynthetic pathway of cholesterol, therapy with ZOCOR would not be expected to cause an accumulation of potentially toxic sterols. In addition, HMG-CoA is also metabolized readily back to acetyl-CoA, which participates in many biosynthetic processes in the body. In animal studies, after oral dosing, simvastatin had high selectivity for the liver, where it achieved substantially higher concentrations than in non-target tissues. Simvastatin undergoes extensive first-pass extraction in the liver, the primary site of action, with subsequent excretion of drug in the Llegiu el document complet