TP-ENRO 200 SOL ENROFLOXACIN 200MGML SOLUTION

País: Malàisia

Idioma: anglès

Font: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

ingredients actius:

ENROFLOXACIN

Disponible des:

Thye Pharma Sdn. Bhd

Designació comuna internacional (DCI):

ENROFLOXACIN

Unidades en paquete:

1l kg

Fabricat per:

Thye Pharma Sdn. Bhd

Fitxa tècnica

Veterinary Package Insert
TP-ENRO
200
SOL
ENROFLOXACIN
200MG/ML
SOLUTION
(20%
Enrofloxacin)
PRODUCT DESCRIPTION
TP-Enro 200 Sol Enrofloxacin 200mg/ml solution is
a pale yellow or light yellow colour liquid, which
contains 20% enrofloxacin, in 1 L bottle.
PHARMACODYNAMICS & PHARMACOKINETICS
Mode of action
Two
enzymes
essential
in
DNA
replication
and
transcription, DNA gyrase and topoisomerase IV,
have been identified as the molecular targets of
fluoroquinolones.
They
modulate
the
topological
state
of
DNA
through
cleaving
and
resealing
reactions. Initially, both strands of the DNA double
helix are cleaved. Then, a distant segment of DNA
is passed through this break before the strands are
resealed.
Target
inhibition
is
caused
by
non-
covalent binding of fluroquinolone molecules to an
intermediate state in this sequence of reactions, in
which
DNA
is
cleaved,
but
both
strands
are
retained
covalently
attached
to
the
enzymes.
Replication
forks
and
translational
complexes
cannot
proceed
beyond
such
enzyme-DNA-
fluroquinolone complexes, and inhibition of DNA
and mRNA synthesis triggers events resulting in a
rapid,
drug
concentration-dependant
killing
of
pathogenic bacteria.
Antibacterial spectrum
Enrofloxacin is active against many Gram-negative
bacteria,
against
Gram-positive
bacteria
and
Mycoplasma spp.
In vitro susceptibility has been shown in strains of (i)
Gram-negative species such as Escherichia coli,
Pasteurella
multocida
and
Avibacterium
(Haemophilus) paragallinarum and (ii) Mycoplasma
gallisepticum and Mycoplasma synoviae.
Enrofloxacin
administered
via
drinking
water
to
poultry
is rapidly
and
very
well
absorbed
with
a
bioavailability
of
approx.
90
%.
In
poultry
enrofloxacin
is
poorly
metabolised
to
its
active
metabolite
ciprofloxacin
(approximately
5%).
Enrofloxacin is eliminated from the body at a half-life
of
6
hours.
Protein
binding
in
poultry
is
approximately 25%.
INDICATION
Treatment of the infections caused by the following
bacteria susceptible to enrofloxacin:
_Chickens _
Mycoplasma gallisepticum,
Mycopla