País: República de Sud-àfrica
Idioma: anglès
Font: South African Health Products Regulatory Authority (SAHPRA)
Aspen-p
THROSYN 150 mg TABLET SCHEDULING STATUS: S4 PROPRIETARY NAME (and dosage form): THROSYN 150 mg TABLET COMPOSITION: Each tablet contains: Roxithromycin 150 mg PHARMACOLOGICAL CLASSIFICATION: A - 20.1.1: Broad and medium spectrum antibiotics PHARMACOLOGICAL ACTION: Roxithromycin is a macrolide antibiotic with a broad spectrum of activity. The mode of action is primarily bacteriostatic, with action against many Gram-positive and some Gram-negative bacteria (the antibacterial spectrum is very similar to that of erythromycin). In vitro sensitivity does not necessarily imply in vivo activity. Gram-positive cocci: • Streptococcus pneumoniae • Streptococcus pyogenes • Staphylococcus aureus (most strains) • Bacillus anthracis • Corynebacterium diphtheriae • Erysipelothrix rhusiopathiae • Listeria monocytogenes Anaerobes: • Clostridium spp. (usually susceptible) • Propionibacterium acnes (vary in susceptibility) Gram-negative cocci usually sensitive: • Neisseria meningitidis • Neisseria gonorrhoeae • Moraxella catarrhalis • Bordatella spp. • some Brucella strains • Flavobacterium • Legionella spp. • Helicobacter pylori • Campylobacter jejuni Other organisms usually sensitive: • Actinomyces • Chlamydia • Rickettsias • Spirochaetes such as Treponema pallidum and Borrelia burgdorferi • Mycoplasma pneumoniae • Mycoplasma pneumoniae • Mycobacterium scrofulaceum • Mycobacterium kanssii Mechanism of action: Roxithromycin binds reversibly to the 5OS subunit of the ribosome, resulting in blockage of the transpeptidation or translocation reactions, inhibition of protein synthesis, and hence inhibition of cell growth. Its action is predominantly bacteriostatic, but high concentrations are slowly bactericidal against the more sensitive strains. Roxithromycin penetrates rapidly into Llegiu el document complet