País: Austràlia
Idioma: anglès
Font: Department of Health (Therapeutic Goods Administration)
Cholestyramine
Aspen Pharma Pty Ltd
Medicine Registered
QUESTRAN LITE- Consumer Medicine Information Page 1 of 4 QUESTRAN® LITE _ _ _cholestyramine resin _ _ _ CONSUMER MEDICINE INFORMATION (CMI) _ _ WHAT IS IN THIS LEAFLET _ _ This leaflet answers some common questions about QUESTRAN LITE. It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist. All medicines have risks and benefits. Your doctor has weighed the risks of you taking QUESTRAN LITE against the benefits they expect it will have for you. IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR OR PHARMACIST. KEEP THIS LEAFLET. You may need to read it again. _ _ _ _ WHAT QUESTRAN LITE IS USED FOR _ _ QUESTRAN LITE is used to reduce high levels of cholesterol in the blood & the prevention of coronary heart disease. The relief of pruritis (itching) associated with the flow of bile being partially blocked. The relief of diarrhoea caused by surgery or disease of the small bowel. QUESTRAN LITE contains cholestyramine (KOL-es-TIE- rameen) which belongs to a group of medicines called resins. It reduces the level of cholesterol in the blood by combining with bile in the small intestine to form an insoluble complex, which is then excreted in faeces. The reduction of blood cholesterol levels help to prevent blockages in the blood vessels to the heart which reduces the likelihood of angina (chest pain with heart disease) & heart attacks QUESTRAN LITE may be used alone or in combination with other medicines. Your doctor will inform you if this is necessary. Your doctor may have prescribed this medicine for another reason. ASK YOUR DOCTOR IF YOU HAVE ANY QUESTIONS ABOUT WHY QUESTRAN LITE WAS PRESCRIBED FOR YOU. There is no evidence tha Llegiu el document complet
QUESTRAN LITE- Product Information Page 1 of 7 PRODUCT INFORMATION QUESTRAN LITE (cholestyramine resin) DESCRIPTION QUESTRAN LITE is a sugar free formulation containing 4g of cholestyramine per 4.7g of QUESTRAN LITE powder. The powder also contains the excipients: Kelcoloid LVF, Xanthan gum, natural and artificial orange juice flavour, aspartame, citric acid and silicon dioxide. Cholestyramine is the chloride salt of a basic anion exchange resin. PHARMACOLOGY Cholesterol is the major, and probably the sole precursor of bile acids. A major portion of the bile acids secreted into the intestine with the bile is reabsorbed and returned to the liver via the portal circulation in an enterohepatic cycle. Only very small amounts of bile acids are found in normal serum. Cholestyramine resin combines with bile acids in the intestine to form an insoluble complex which is excreted in the faeces. This process results in a continuous, though partial, removal of bile acids from enterohepatic circulation by preventing their reabsorption. Besides bile acids, some other anions are strongly bound to the resin, but cations or neutral compounds are usually less firmly bound. The increased loss of bile acids due to cholestyramine administration leads to increased oxidation of cholesterol to bile acids, a decrease in beta lipoprotein or low density lipoprotein in plasma and a decrease in serum cholesterol levels. Although in man cholestyramine produces an increase in hepatic synthesis of cholesterol, plasma cholesterol levels fall. Apparently this fall is secondary to an increased clearance of cholesterol rich lipoproteins from plasma. Serum triglyceride levels may increase or remain unchanged in pat Llegiu el document complet