PYRIDOSTIGMINE BROMIDE tablet

País: Estats Units

Idioma: anglès

Font: NLM (National Library of Medicine)

ingredients actius:

PYRIDOSTIGMINE BROMIDE (UNII: KVI301NA53) (PYRIDOSTIGMINE - UNII:19QM69HH21)

Disponible des:

McKesson Corporation dba RX Pak

Vía de administración:

ORAL

tipo de receta:

PRESCRIPTION DRUG

indicaciones terapéuticas:

Pyridostigmine bromide tablets are useful in the treatment of myasthenia gravis. Pyridostigmine bromide tablets are contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.

Resumen del producto:

Tablets, are available as white, flat-faced tablets containing 60 mg pyridostigmine bromide in bottles of 90 (NDC 71930-028-90). Each tablet is white to off-white, round, flat-faced tablet debossed with "C 60" on one side and quadrisect scored on the other side.  Store at 25˚C (77˚F); excursions permitted between 15˚ to 30˚C (59˚ to 86˚F). [See USP Controlled Room Temperature]. Preserve in a tight, light-resistant container. Keep pyridostigmine bromide tablets, USP in a dry place with the silica gel enclosed.

Estat d'Autorització:

Abbreviated New Drug Application

Fitxa tècnica

PYRIDOSTIGMINE BROMIDE - PYRIDOSTIGMINE BROMIDE TABLET
MCKESSON CORPORATION DBA RX PAK
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PYRIDOSTIGMINE BROMIDE TABLETS ,USP
DESCRIPTION
Pyridostigmine bromide tablets, USP (pyridostigmine bromide) are an
orally active cholinesterase
inhibitor. Chemically, pyridostigmine bromide is
3-hydroxy-1-methylpyridinium bromide
dimethylcarbamate. Its structural formula is:
Pyridostigmine bromide tablets,USP are available in the following
form:
Tablets containing 60 mg pyridostigmine bromide; each tablet also
contains anhydrous lactose,
colloidal silicon dioxide and stearic acid.
CLINICAL PHARMACOLOGY
Pyridostigmine bromide tablets inhibit the destruction of
acetylcholine by cholinesterase and thereby
permits freer transmission of nerve impulses across the neuromuscular
junction. Pyridostigmine is an
analog of neostigmine (Prostigmin
), but differs from it in certain clinically significant respects; for
example, pyridostigmine is characterized by a longer duration of
action and fewer gastrointestinal side
effects.
INDICATIONS AND USAGE
Pyridostigmine bromide tablets are useful in the treatment of
myasthenia gravis.
CONTRAINDICATIONS
Pyridostigmine bromide tablets are contraindicated in mechanical
intestinal or urinary obstruction, and
particular caution should be used in its administration to patients
with bronchial asthma. Care should be
observed in the use of atropine for counteracting side effects, as
discussed below.
WARNINGS
Although failure of patients to show clinical improvement may reflect
under dosage, it can also be
indicative of overdosage. As is true of all cholinergic drugs,
overdosage of pyridostigmine bromide
may result in cholinergic crisis, a state characterized by increasing
muscle weakness which, through
involvement of the muscles of respiration, may lead to death.
Myasthenic crisis due to an increase in the
severity of the disease is also accompanied by extreme muscle
weakness, and thus may be difficult to
distinguish from cholinergic crisis on a symptomatic basis. Such
differentiation is extre