PENICILLIN V POTASIUM tablet

País: Estats Units

Idioma: anglès

Font: NLM (National Library of Medicine)

ingredients actius:

PENICILLIN V POTASSIUM (UNII: 146T0TU1JB) (PENICILLIN V - UNII:Z61I075U2W)

Disponible des:

Physicians Total Care, Inc.

Designació comuna internacional (DCI):

PENICILLIN V POTASSIUM

Composición:

PENICILLIN V 250 mg

Vía de administración:

ORAL

tipo de receta:

PRESCRIPTION DRUG

indicaciones terapéuticas:

Penicillin V potassium tablets are indicated in the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms. Therapy should be guided by bacteriological studies (including sensitivity tests) and by clinical response. NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis should not be treated with penicillin V during the acute stage. Indicated surgical procedures should be performed. The following infections will usually respond to adequate dosage of penicillin V. Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas. NOTE: Streptococci in groups A, C, G, H, L, and M are very sensitive to penicillin. Other groups, including group D (enterococcus), are resistant. Mild to moderately severe infections of the respiratory tract. Mild infections of the skin and soft tissues. NOTE: Reports indicate an increasing number of strains of staphylococci resistant to penicillin G, emphasizing the need for culture an

Resumen del producto:

Penicillin-VK Tablets (Penicillin V Potassium Tablets USP), 250 mg (400,000 units) are round, biconvex white tablets, debossed PVK 250 and break scored on one side and GG 949 on the reverse side. NDC 54868-1171-0 bottles of 20 NDC 54868-1171-5 bottles of 28 NDC 54868-1171-3 bottles of 30 NDC 54868-1171-1 bottles of 40 Penicillin-VK Tablets (Penicillin V Potassium Tablets USP), 500 mg (800,000 units) are oblong, biconvex white tablets, debossed PVK 500 on one side and GG 950 on the reverse side and break scored on both sides. NDC 54868-1173-5 bottles of 20 NDC 54868-1173-1 bottles of 30 Store at 20°-25°C (68°-77°F) (see USP Controlled Room Temperature). Keep tightly closed. Dispense in a tight container, as defined in the USP.

Estat d'Autorització:

Abbreviated New Drug Application

Fitxa tècnica

PENICILLIN V POTASIUM - PENICILLIN V POTASIUM TABLET
PHYSICIANS TOTAL CARE, INC.
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PENICILLIN-VK
PENICILLIN V POTASSIUM TABLETS, USP
250 MG (400,000 UNITS)
500 MG (800,000 UNITS)
To reduce the development of drug-resistant bacteria and maintain the
effectiveness of penicillin-VK
and other antibacterial drugs, penicillin-VK should be used only to
treat or prevent infections that are
proven or strongly suspected to be caused by bacteria.
DESCRIPTION
Penicillin V is the phenoxymethyl analog of penicillin G.
Penicillin V potassium is the potassium salt of penicillin V.
Molecular Formula: C
H O KN S Molecular Weight: 388.5
Penicillin -VK (Penicillin V Potassium Tablets USP), for oral
administration, contain 250 mg (400,000
units) or 500 mg (800,000 units) penicillin V. In addition, each
tablet contains the following inactive
ingredients: hydroxypropyl methylcellulose, magnesium stearate,
polyethylene glycol, povidone, talc,
and titanium dioxide.
CLINICAL PHARMACOLOGY
Penicillin V exerts a bactericidal action against penicillin-sensitive
microorganisms during the stage of
active multiplication. It acts through the inhibition of biosynthesis
of cell-wall mucopeptide. It is not
active against the penicillinase-producing bacteria, which include
many strains of staphylococci. The
drug exerts high _in vitro_ activity against staphylococci (except
penicillinase-producing strains),
streptococci (groups A, C, G, H, L and M), and pneumococci. Other
organisms sensitive _in vitro_ to
penicillin V are _Corynebacteriumdiphtheriae, Bacillus anthracis,
Clostridia, Actinomycesbovis,_
_Streptobacillusmoniliformis, Listeria monocytogenes, Leptospira, and
Neisseria gonorrhoeae._
_Treponemapallidum_ is extremely sensitive.
The potassium salt of penicillin V has the distinct advantage over
penicillin G in resistance to
inactivation by gastric acid. It may be given with meals; however,
blood levels are slightly higher when
the drug is given on an empty stomach. Average blood levels are two to
five times higher than the
levels follo