MISTROM metoprolol tartrate 50mg tablet blister pack

País: Austràlia

Idioma: anglès

Font: Department of Health (Therapeutic Goods Administration)

ingredients actius:

metoprolol tartrate

Disponible des:

Strides Pharma Science Pty Ltd

Designació comuna internacional (DCI):

Metoprolol tartrate

Estat d'Autorització:

Registered

Informació per a l'usuari

MISTROM™
CONSUMER MEDICINE INFORMATION
Metoprolol tartrate 50 mg and 100 mg
WHAT IS IN THIS LEAFLET
This leaflet answers some of the common questions about MISTROM.
It does not contain all the information that is known about MISTROM.
It does not take the place of
talking to your doctor and pharmacist.
All medicines have risks and benefits. Your doctor will have weighed
the risks of you taking this
medicine against the benefits they expect it will have for you.
IF YOU HAVE ANY CONCERNS ABOUT TAKING THIS MEDICINE, ASK YOUR DOCTOR
OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE. You may need to read it again.
WHAT MISTROM IS USED FOR
MISTROM is used:
1. to lower high blood pressure, also called hypertension;
2. to prevent a type of chest pain, also called angina;
3. after a heart attack; and
4. to prevent migraine headaches.
HYPERTENSION
Everyone has blood pressure. This pressure helps to move your blood
around your body. Your
blood pressure may be different at various times of the day, depending
on how busy you are. You
have hypertension (high blood pressure) when your blood pressure stays
higher than is needed,
even when you are calm and relaxed. If high blood pressure is not
treated it can lead to serious
health problems, including stroke, heart disease and kidney failure.
There are usually no symptoms of hypertension. The only way of knowing
that you have it is to
have your blood pressure checked on a regular basis. You may feel fine
and have no symptoms
but, if high blood pressure is not treated, it can lead to serious
health problems. MISTROM helps to
lower your blood pressure.
ANGINA
Angina is a pain or uncomfortable feeling in the chest, often
spreading to the arms or neck and
sometimes to the shoulders and back. This may be caused by too little
blood and oxygen getting to
the heart. The pain of angina is usually brought on by exercise or
stress but it can also happen
while you are resting.
MISTROM helps to prevent angina from happening. It is not used to
treat a sudden attack.
REDUCING HEART COMPLICATI

Fitxa tècnica

Page 1 of 17
PRODUCT INFORMATION
MISTROM™
TABLETS
NAME OF THE MEDICINE
Active ingredient:
Metoprolol tartrate
Chemical name:
Bis[(2_RS_)-1-[4-(2-methoxyethyl)phenoxy]-3-[(1-
methylethyl)amino]propan-2-ol] (2_R_,3_R_)-2,3-
dihydroxybutanedioate
CAS number:
56392-17-7
Molecular weight:
685
Molecular formula:
C
34
H
56
N
2
O
12
.C
4
H
6
O
6
Chemical structure:
DESCRIPTION
Metoprolol tartrate is an aryloxypropanolamine derivative. It is a
white, odourless or
almost odourless, crystalline powder with a melting point of 120°C.
It is very soluble in
water, soluble in chloroform, methylene chloride and alcohol, and
almost insoluble in
benzene, diethyl ether and acetone.
Mistrom tablets contain either 50 mg or 100 mg of metoprolol tartrate.
They also contain
lactose, colloidal anhydrous silica, microcrystalline cellulose,
croscarmellose sodium,
pregelatinised maize starch, sodium starch glycolate, magnesium
stearate, hypromellose,
purified talc, macrogol 400 and titanium dioxide. The 50 mg strength
tablets also contain
iron oxide red.
PHARMACOLOGY
_PHARMACODYNAMIC PROPERTIES _
Pharmacotherapeutic group: cardio-selective beta-blocker; ATC Code:
C07A B02.
Page 2 of 17
_PHARMACOLOGICAL ACTIONS _
Metoprolol, the active substance of Mistrom, is a relatively
cardioselective beta-blocker,
i.e. it acts on beta
1
-receptors mainly located in the heart at lower doses than those
needed to influence the beta
2
-receptors mainly located in the bronchi and peripheral
vessels.
Metoprolol has little membrane-stabilising effect nor does it display
partial agonist activity
(i.e. intrinsic sympathomimetic activity = ISA) at doses required to
produce beta-blockade.
PHARMACODYNAMICS
The stimulant effect of catecholamines on the heart is reduced or
inhibited by metoprolol.
This leads to a decrease in heart rate, cardiac contractility, and
cardiac output.
Metoprolol lowers elevated blood pressure in both the standing and
lying position. It also
reduces the extent of rises in blood pressure occurring in response to
physical and
mental stress.