Exemestane Pfizer

País: Austràlia

Idioma: anglès

Font: Department of Health (Therapeutic Goods Administration)

ingredients actius:

Exemestane

Disponible des:

Pfizer Australia Pty Ltd

clase:

Medicine Registered

Informació per a l'usuari

EXEMESTANE PFIZER
®

_Exemestane_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about EXEMESTANE
PFIZER.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking
EXEMESTANE PFIZER against the
benefits it is expected to have for
you.
IF YOU HAVE ANY CONCERNS ABOUT THIS
MEDICINE, ASK YOUR DOCTOR OR
PHARMACIST.
KEEP THIS LEAFLET.
You may need to read it again.
WHAT EXEMESTANE
PFIZER IS USED FOR
EXEMESTANE PFIZER is used to
treat breast cancer in women who no
longer have their menstrual periods,
either naturally due to their age (after
menopause) or because they have
had their ovaries surgically removed.
EXEMESTANE PFIZER is used to
reduce the risk of recurrence or
spreading of the breast cancer. It is
also used when the cancer has not
responded or has returned after
treatment with another medicine or
medicines.
_HOW EXEMESTANE PFIZER_
_WORKS_
EXEMESTANE PFIZER is an
aromatase inactivator. It works by
significantly reducing the supply of
oestrogen to cancer cells.
This stops the growth of those cancer
cells which need oestrogen, a natural
female sex hormone, to grow.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY
EXEMESTANE PFIZER HAS BEEN
PRESCRIBED FOR YOU.
Your doctor may have prescribed it
for another purpose.
EXEMESTANE PFIZER is only
available with a doctor's prescription.
It is not addictive.
BEFORE YOU TAKE
EXEMESTANE PFIZER
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE EXEMESTANE
PFIZER AND TALK TO YOUR DOCTOR IF
YOU THINK YOU MAY HAVE AN ALLERGY
TO:
•
exemestane, the active ingredient
in EXEMESTANE PFIZER
•
any of the other ingredients in
EXEMESTANE PFIZER listed at
the end of this leaflet.
Symptoms of an allergic reaction
may include shortness of breath,
wheezing or difficulty breathing;
swelling of the face, lips, tongue or
other parts of the body; rash, itching
or hives on the skin.
DO NOT

Fitxa tècnica

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PRODUCT INFORMATION 
EXEMESTANE PFIZER
®
 TABLETS 25 MG (EXEMESTANE) 
NAME OF THE MEDICINE 
Non-proprietary name: 
Exemestane 
Chemical name: 

6-methylenandrosta-1,4-diene-3,17-dione 
Chemical structure: 

CAS Number:  

CAS-107868-30-4 
DESCRIPTION 
Exemestane is a  white or yellowish-white powder, which
is freely soluble in 
N,N-dimethylformamide, soluble in methanol and practically
insoluble in water.  Due to the 
very low solubility in water, the drug is micronised.   
EXEMESTANE PFIZER tablets are sugar-coated tablets for oral
administration.  In addition 
to exemestane, the tablets contain colloidal hydrated silica,
crospovidone, hypromellose, light 
magnesium carbonate, magnesium stearate, mannitol, microcrystalline
cellulose, methyl 
hydroxybenzoate, macrogol 6000, polysorbate 80,
polyvinyl alcohol, simethicone, sodium 
starch glycollate, sucrose, titanium dioxide, cetyl esters wax,
purified talc and carnauba wax.  
The tablets are imprinted “7663” on one side with black
printing ink. 
PHARMACOLOGY 
PHARMACODYNAMICS 
Exemestane is an irreversible, steroidal
aromatase inactivator, structurally related to the 
natural substrate androstenedione.  In post-menopausal women,
oestrogens are produced 
primarily from the conversion
of androgens into oestrogens through the aromatase enzyme in 
peripheral tissues.  Oestrogen deprivation through
aromatase inhibition is an effective and 
selective
treatment for hormone dependent breast cancer in postmenopausal women.  
Exemestane acts by binding irreversibly to the active site
of the enzyme causing its 
inactivation.  Such type of inactivation is also known
as “suicidal inhibition”.  In 
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postmenopausal women, EXEMESTANE PFIZER  significantly
lo