Eldepryl

País: Austràlia

Idioma: anglès

Font: Department of Health (Therapeutic Goods Administration)

ingredients actius:

Selegiline hydrochloride

Disponible des:

Aspen Pharmacare Australia Pty Ltd

clase:

Medicine Registered

Informació per a l'usuari

ELDEPRYL™

_selegiline hydrochloride 5 mg tablets_
CONSUMER MEDICINE INFORMATION (CMI)

WHAT IS IN THIS LEAFLET
This leaflet answers some of the
common questions about
ELDEPRYL tablets. It does not
contain all the available information.
It does not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking ELDEPRYL
tablets against the benefits the
medicine is expected to have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE MEDICINE.
You may need to read it again.
WHAT ELDEPRYL IS
USED FOR
ELDEPRYL tablets are used to treat
the symptoms of Parkinson's disease.
This is a disease of the brain that
affects movement.
People with Parkinson's disease do
not have enough nerve cells in the
part of the brain that controls
movement. These nerve cells
produce a substance called
dopamine. It is a lack of dopamine
which causes problems with
movement.
ELDEPRYL tablets keep dopamine
around longer, helping with
difficulties in movement.
BEFORE YOU TAKE IT
_WHEN YOU MUST NOT TAKE IT_
DO NOT TAKE ELDEPRYL TABLETS IF:
1. you have ever had an allergic
reaction to:
•
medicines containing selegiline
•
any of the ingredients listed at the
end of this leaflet.
2. you have taken or are taking
antidepressants known as
selective serotonin reuptake
inhibitors (SSRIs) such as
Prozac® (fluoxetine), Aropax®
(paroxetine) or Zoloft®
(sertraline) within the last five
weeks.
3. you are taking pethidine (a strong
pain killer) or other opiates
(check with your doctor or
pharmacist). Serious side effects
could occur if you start to take
ELDEPRYL tablets at the same
time as these medicines.
4. you are taking antidepressants
known as monoamine oxidase
inhibitors (MAOIs) such as
Aurorix® (moclobemide),
Nardil® (phenelzine) or Parnate®
(tranylcypromine) or have taken
these medications within the last
two weeks.
5. you are taking antidepressants
known as tricyclic antidepr

Fitxa tècnica

ELDEPRYL Product Information 

Page 1 of 10 
PRODUCT INFORMATION 

ELDEPRYL


(SELEGILINE HYDROCHLORIDE)

NAME OF THE MEDICINE 

ELDEPRYL  (selegiline  hydrochloride)  is  a  laevorotatory  acetylenic  derivative  of  phenethylamine.  It  is  also 
known  as  L-deprenyl.  Its  chemical  name  is  (R)-methyl  (-methylphenylethyl)  prop-2-ynlamine  hydrochloride.  
The structural formula is: 

CAS No.: 2079-54-1 

DESCRIPTION 

It  is  a  white  to  near-white  crystalline  powder,  freely  soluble  in  water,  chloroform  and  methanol  and  has  a 
molecular weight of 223.75. 

Each round white tablet contains 5
mg selegiline hydrochloride. Inactive ingredients are:
maize starch, cellulose 
(microcrystalline), mannitol, povidone and magnesium stearate. 

PHARMCOLOGY 
_ _
_PHARMACODYNAMICS _
Selegiline is an irreversible inhibitor of monoamine oxidase (MAO), an intracellular enzyme associated with the 
outer membrane of mitochondria. Selegiline inhibits MAO by acting as a 'suicide' substrate for the enzyme: that 
is, it is converted by MAO to an active moiety that combines irreversibly with the active site of the enzyme and / 
or  the  enzyme's  essential  flavine  adenine  dinucleotide  (FAD)  co-factor.  MAOs  are  currently  subclassified  into 
two types, A and B, which differ in their substrate specificity and tissue distribution. In humans, intestinal MAO 
is  predominantly  type-A,  while  most  of  that  in  the  brain  is  type-B.  At  the  recommended  dose,  selegiline  has 
greater affinity with type-B than for type-A active sites and serves as a selective inhibitor of MAO type-B (MAO-
B).  However,  this  selectivity  is  dose-dependent  and  at  higher  doses  (above