COXIRIL® 0.5% ww Premix FOR medicated feeding stuff

País: Malàisia

Idioma: anglès

Font: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)

ingredients actius:

DICLAZURIL

Disponible des:

PAHANG PHARMACY SDN. BHD.

Designació comuna internacional (DCI):

DICLAZURIL

Unidades en paquete:

20 kg

Fabricat per:

Biovet Joint Stock Company

Fitxa tècnica

®
COXIRIL 0.5%
W/W
LfB2427v1Cox0.5vmp-fa-MAL1217
PREMIX FOR MEDICATED FEEDING STUFF
STATEMENT OF ACTIVE SUBSTANCE:
Diclazuril – 5 g/kg
PRODUCT DESCRIPTION:
COXIRIL ® 0.5% w/w Premix for medicated feeding
stuff represents granules of off-white to beige colour
intended for administration through feed of broiler
chickens and growing turkeys.
PHARMACODYNAMICS:
Diclazuril,
a
benzeneacetonitrile
derivative,
is
a
synthetic compound of the triazinone family.
According
to
the
anticoccidial
properties
of
triazinones, diclazuril is active against intracellular
development
stages
of
coccidia,
namely
during
schizogony and gametogony.
After
diclurazil
treatment,
the
first-
and
second-
generation schizonts show extensive degenerative
changes
which
are
characterised
by
the
loss
of
internal
structure,
the
appearance
of
many
intracytoplasmic vacuoles and incomplete merogony.
Ultrastructural
findings
indicate
that
diclazuril
treatment primarily affects the normal differentiation of
the respective endogenous stages during parasite
development. This leads to complete degeneration of
schizonts and gamonts.
PHARMACOKINETICS:
Biotransformation of diclazuril in chicken and turkey is
low and the major compound found in plasma, tissues,
urine and feces is the parent substance. Although
poorly absorbed, diclazuril is detectable in plasma
soon after administration with a tmax of about 6 hours.
INDICATIONS FOR USE:
As an aid in the prevention of coccidiosis in:
- Broiler chickens caused by _ Eimeria acervulina, _
_E.maxima, _
_E. _
_mitis, _
_E. _
_brunetti, _
_E. _
_necatrix _
and
_E.tenella_
-
Growing
turkeys
caused
by
_E. _
_adenoeides, _
_E.gallopavonis _and _E. meleagrimitis_
RECOMMENDED DOSE:
Broiler chicken:
1
mg/kg
(milligram
per
kilogram)
(0.0001%)
of
complete feed
Growing turkeys:
1
mg/kg
(milligram
per
kilogram)
(0.0001%)
of
complete feed
DIRECTIONS FOR USE:
For oral administration through the feed.
Broiler chicken:
To achieve 0.0001% concentration of diclazuril in
complete feed, mix 200 g of COXIRIL ® 0.5% w/w
Premix
for
medi