Country: আর্মেনিয়া
ভাষা: ইংরেজি
সূত্র: Դեղերի և բժշկական տեխնոլոգիաների փորձագիտական կենտրոնի գործունեության Հայաստանի Հանրապետությունում
lercanidipine (lercanidipine hydrochloride)
Recordati Industria Chimica e Farmaceutica S.p.A.
C08CA13
lercanidipine (lercanidipine hydrochloride)
20mg
tablets film-coated
(28/2x14/) in blister
Prescription
Registered
2016-07-11
Summary of Product Characteristics (SmPC) for Zanidip®-Recordati Marketing authorization number: Trade name: Zanidip®-Recordati International non-patented name (INN): lercanidipine Pharmaceutical form: film-coated tablets Contents Each film-coated tablet contains: Active component: lercanidipine hydrochloride 10 mg or 20 mg; Excipients: lactose monohydrate 30 mg/60 mg, microcrystalline cellulose 39 mg/78 mg, sodium starch glycolate 15.5 mg/31 mg, povidone K30 4.5 mg/9 mg, magnesium stearate 1 mg/2 mg; Film coating: for 10 mg tablets – Opadry yellow (OY-SR-6479) 3 mg (hypromellose, talc, titanium dioxide (E171), macrogol 6000, ferric oxide yellow (E172); for 20 mg tablets - Opadry pink (OY-SR-6479) 6 mg (hypromellose, talc, titanium dioxide (E171), macrogol 6000, ferric oxide red (E172)). Description 10 mg tablets: round-shaped biconvex tablet with a light yellow film coating, with a breaking line on one side, light yellow at the fracture surface. 20 mg tablets: round-shaped biconvex tablet with a pink to dark pink film coating, with a breaking line on one side, light yellow at the fracture surface. Therapeutic category “Slow” calcium channels blocker. ATC code: C08CA13. Pharmacological properties Pharmacodynamics. “Slow” calcium channels blocker. Lercanidipine is a racemic mixture of right- (R) and left- (L) rotating stereomers, a derivative of 1,4-dyhydropyridine, which is able to selectively block the calcium ions current into the cells of blood vessels walls, heart cells and smooth muscle cells. Lercanidipine has prolonged antihypertensive action. The therapeutic effect is reached 5 to 7 hours after the oral administration and is maintained during 24 hours. Due to high selectivity for the cells of smooth muscles of the blood vessels, there is no negative inotropic effect. Lercanidipine is a metabolically neutral drug, and it does not have any substantial effect on serum lipoproteins and alipoproteins level, as well as does not change the lipid profile in hypertension patients. Pharmacokinetics: _-_ সম্পূর্ণ নথি পড়ুন