Vfend

দেশ: অস্ট্রেলিয়া

ভাষা: ইংরেজি

সূত্র: Department of Health (Therapeutic Goods Administration)

সক্রিয় উপাদান:

Voriconazole

থেকে পাওয়া:

Pfizer Australia Pty Ltd

শ্রেণী:

Medicine Registered

তথ্য লিফলেট

VFEND
®

_TABLETS, IV INJECTION AND ORAL SUSPENSION_
_Voriconazole (vori-con-a-zole)_
CONSUMER MEDICINE INFORMATION

WHAT IS IN THIS LEAFLET
This leaflet answers some common
questions about VFEND.
It does not contain all the available
information. It does not take the
place of talking to your doctor or
pharmacist.
All medicines have risks and
benefits. Your doctor has weighed
the risks of you taking VFEND
against the benefits they expect it
will have for you.
IF YOU HAVE ANY CONCERNS ABOUT
TAKING THIS MEDICINE, ASK YOUR
DOCTOR OR PHARMACIST.
READ THIS LEAFLET CAREFULLY BEFORE
TAKING VFEND AND KEEP THIS
LEAFLET.
You may need to read it again.
WHAT VFEND IS USED
FOR
VFEND is used to treat fungal and
yeast infections such as:
•
invasive aspergillosis (as-pur-ji-
losis), a fungal infection caused
by a fungus called Aspergillus
(as-pur-jilus), which usually
begins in the respiratory tract (in
the nose, sinuses or lungs).
Aspergillus is harmless in most
healthy people; however, in
people with poor immune
systems (such as people who have
had organ transplants and people
with cancer or HIV/AIDS)
invasive aspergillosis can be
serious and spread to other tissues
and organs.
•
serious Candida (can-did-da)
infections, including Candida
infections of the oesophagus
(food pipe or gullet) and those
that have spread into the blood
stream or to other parts of the
body.
•
serious fungal infections caused
by Scedosporium (ski-doe-spore-
rium) species and Fusarium (few-
saa-rium) species.
•
other serious fungal infections in
patients who do not respond to, or
cannot tolerate, other antifungal
medicines.
Vfend is also used to prevent
invasive fungal infections in patients
who are at risk of developing such
infections.
This medicine belongs to a group of
medicines called triazole antifungals.
This medicine works by preventing
the growth of fungal and yeast
organisms causing your infection.
ASK YOUR DOCTOR IF YOU HAVE ANY
QUESTIONS ABOUT WHY THIS MEDICINE
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have prescrib

পণ্য বৈশিষ্ট্য

Version: pfpvfend10913 
Supersedes: pfpvfend10113 

Page 1 of 38

PRODUCT INFORMATION 
VFEND® TABLETS, IV POWDER FOR INJECTION AND POWDER FOR ORAL 
SUSPENSION 
NAME OF THE MEDICINE

Voriconazole 
The structural formula is: 

F
F
CH
3
N
N
F
OH
N
N
N

CAS number 137234-62-9 
Voriconazole  is  designated  chemically  as  (2R,  3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-4-
pyrimidinyl)-1-(1_H _-1,2,4-triazol-1-yl)-2-butanol with  an empirical  formula of C
16
H
14
F
3
N
5
O 
and a molecular weight of 349.3. 
DESCRIPTION  
Voriconazole, a broad-spectrum, triazole antifungal agent, is available as film-coated tablets 
for oral administration, a powder for oral suspension and as a lyophilised powder for solution 
for intravenous infusion. 
Voriconazole drug substance is a white to off white powder. Its aqueous solubility is
very low 
at 0.7 mg/mL at 25ºC. 
FILM-COATED TABLETS 
VFEND  Tablets  contain  50  mg  or  200  mg  of  voriconazole  and  the  following  inactive 
ingredients:  lactose,  pregelatinised  maize  starch,  croscarmellose  sodium,  povidone, 
magnesium  stearate  and  a  coating  containing  hypromellose,  titanium  dioxide,  lactose  and 
glycerol triacetate. 
Version: pfpvfend10913 
Supersedes: pfpvfend10113 

Page 2 of 38

POWDER FOR INJECTION 
VFEND  IV  is  a  white  lyophilised  powder  containing  nominally  200 mg  voriconazole  in  a 
30 mL  Type  I  clear  glass  vial.  VFEND  IV  is  intended  for  administration  by  intravenous 
infusion. It is a single dose, unpreserved product. 
The lyophilised powder contents of the VFEND 200 mg vials are intended for reconstitution 
with 19 mL Water for Injections to produce a solution
containing 10 mg/mL voriconazole and 
160 mg/mL of sulfobutyl betadex sodium (SBECD). The r