Country: মার্কিন যুক্তরাষ্ট্র
ভাষা: ইংরেজি
সূত্র: NLM (National Library of Medicine)
ivermectin (UNII: 8883YP2R6D) (ivermectin - UNII:8883YP2R6D), clorsulon (UNII: EG1ZDO6LRD) (clorsulon - UNII:EG1ZDO6LRD)
MWI/VetOne
ivermectin
ivermectin 10 mg in 1 mL
SUBCUTANEOUS
OTC
VetrimecTM Plus Injection is indicated for the effective treatment and control of the following parasites in cattle: Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi ) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus Liver Flukes: Fasciola hepatica (adults only) Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus Mange Mites (cattle scab*): Psoroptes ovis (syn. P. communis var. bovis ) Sarcoptes scabiei var. bovis Ivermectin and clorsulon injection has been proved to effectively control infections and to protect cattle from reinfection with Dictyocaulus viviparus and Oesophagostomum radiatum for 28 days
VetrimecTM Plus Injection is available in five ready-to-use pack sizes: The 50 mL pack is a multiple-dose, rubber-capped bottle. Each bottle contains sufficient solution to treat 10 head of 550 lb (250 kg) cattle. The 100 mL pack is a multiple-dose, rubber-capped bottle. Each bottle contains sufficient solution to treat 20 head of 550 lb (250 kg) cattle. The 250 mL pack is a multiple-dose, rubber-capped bottle designed for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 50 head of 550 lb (250 kg) cattle. The 500 mL pack is a multiple-dose, rubber-capped bottle designed for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 100 head of 550 lb (250 kg) cattle. The 1000 mL pack is a multiple-dose, rubber-capped bottle designed for use with automatic syringe equipment. Each bottle contains sufficient solution to treat 200 head of 550 lb (250 kg) cattle. Restricted Drug - California. Use Only as Directed. Made in the UK. Manufactured by: Norbrook Laboratories Limited, Newry, Co. Down, Northern Ireland. Distributed by: MWI Boise, ID 83705 www.VetOne.net Approved by FDA under ANADA # 200-436 VET one® Rev. 10/21
Abbreviated New Animal Drug Application
VETRIMEC PLUS FOR CATTLE - IVERMECTIN AND CLORSULON INJECTION, SOLUTION MWI/VETONE ---------- VETONE VETRIMEC PLUS (ivermectin and clorsulon) INJECTION FOR CATTLE INJECTION FOR CATTLEFOR THE EFFECTIVE TREATMENT AND CONTROL OF INTERNAL PARASITES, INCLUDING ADULT LIVER FLUKES, AND EXTERNAL PARASITES. CONSULT YOUR VETERINARIAN FOR ASSISTANCE IN THE DIAGNOSIS, TREATMENT AND CONTROL OF PARASITISM. INTRODUCTION The ability of ivermectin to deliver internal and external parasite control has been proven in cattle markets around the world. Now, Vetrimec Plus combines ivermectin with clorsulon, an effective adult flukicide. A single injection of Vetrimec Plus (ivermectin and clorsulon) offers all the benefits of an ivermectin injection plus control of adult _Fasciola hepatica._ THE DOSAGE LEVEL OF CLORSULON SUPPLIED BY VETRIMEC PLUS IS EFFECTIVE ONLY AGAINST ADULT LIVER FLUKES _(FASCIOLA HEPATICA)._ PRODUCT DESCRIPTION Vetrimec Plus is a ready-to-use sterile solution containing 1% w/v ivermectin, 10% clorsulon, 40% glycerol formal, and propylene glycol, q.s. ad 100%. It is formulated to deliver the recommended dose level of 200 mcg ivermectin/kg and 2 mg clorsulon/kg given subcutaneously behind the shoulder at the rate of 1 mL per 110 lb (50 kg) body weight. MODE OF ACTION Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA). The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic সম্পূর্ণ নথি পড়ুন