Urex Forte

দেশ: নিউ জিলণ্ড

ভাষা: ইংরেজি

সূত্র: Medsafe (Medicines Safety Authority)

সক্রিয় উপাদান:

Furosemide 500mg;  

থেকে পাওয়া:

Arrotex Pharmaceuticals (NZ) Limited

INN (আন্তর্জাতিক নাম):

Furosemide 500 mg

ডোজ:

500 mg

ফার্মাসিউটিকাল ফর্ম:

Tablet

রচনা:

Active: Furosemide 500mg   Excipient: Colloidal silicon dioxide Lactose Magnesium stearate Maize starch Maltodextrin

প্যাকেজ ইউনিট:

Blister pack, PVC/Al, 50 tablets

শ্রেণী:

Prescription

প্রেসক্রিপশন টাইপ:

Prescription

Manufactured by:

Ipca Laboratories Limited

থেরাপিউটিক ইঙ্গিত:

Frusemide in a high-dosage formulation such as UREX FORTE (500 mg tablets) is intended exclusively for patients with severely impaired renal function. For use under strict medical supervision only within a hospital setting. High doses of frusemide may be used as an adjuvant treatment of oliguria and in the promotion of diuresis in the treatment of oedema; in selected patients with acute renal failure, e.g. in the post-operative phase and in association with septic infections; in selected patients with chronic renal failure with fluid retention, both in the pre-dialysis phase and when dialysis has become unavoidable, especially in the presence of acute pulmonary oedema; in selected patients with the nephrotic syndrome with severe impairment of renal function e.g. in chronic glomerulonephritis, lupus erythematous and Kimmelstiel-Wilson syndrome. If diuresis is less than 2.5 L/day dialysis has to be used.

পণ্য সারাংশ:

Package - Contents - Shelf Life: Blister pack, PVC/Al - 50 tablets - 24 months from date of manufacture stored at or below 30°C - Bottle, glass, 75 mL round amber bottle with a 38 mm white HDPE/PP wadded Clic Loc Child Resistant closure - 50 tablets - 2 years from date of manufacture stored at or below 30°C protect from light

অনুমোদন তারিখ:

2010-03-12

তথ্য লিফলেট

UREX
®
, UREX
®
-M, UREX
®
FORTE - Consumer Medicine Information
Page 1 of 7
UREX
®
-M
UREX
®
UREX
® FORTE
_Furosemide (frusemide) _
_ _
CONSUMER MEDICINE INFORMATION (CMI)
WHAT IS IN THIS LEAFLET
This leaflet answers some
common questions about this
medicine which is available in
tablets of three different
strengths. Urex-M is a 20-mg
tablet, Urex is a 40 mg tablet,
and Urex Forte is a 500 mg
tablet.
It does not contain all of the
available information. It does
not take the place of talking to
your doctor or pharmacist.
All medicines have risks and
benefits. Your doctor has
weighed the risks of you or
your child taking Urex against
the benefits they expect it will
have.
IF YOU HAVE ANY CONCERNS
ABOUT TAKING THIS MEDICINE,
ASK YOUR DOCTOR OR PHARMACIST.
KEEP THIS LEAFLET WITH THE
MEDICINE.
You may need to read it again.
WHAT UREX IS USED FOR
The active ingredient in Urex is
called frusemide which belongs
to a group of medicines called
diuretics. Diuretics are used to
help the kidneys remove
excess fluid from the body.
Urex is used to treat a number
of medical conditions,
including:
_ _
•
oedema (swelling of the
body, ankles, feet, legs or
even the brain or lungs due
to excess fluid).
This problem can also occur
in cases of heart, liver or
kidney disease.
•
hypertension (high blood
pressure).
This can occur by itself or in
severe heart, liver or kidney
disease.
Everyone has blood pressure.
This pressure helps move your
blood around your body. Your
blood pressure may vary at
different times of the day,
depending on how busy or
worried you are. You have
hypertension (high blood
pressure) when your blood
pressure stays higher than is
needed, even when you are
calm and relaxed.
If high blood pressure is not
treated it can lead to serious
health problems, including
stroke, heart disease and
kidney failure.
Urex may be taken alone or in
combination with other
medicines to treat your
condition.
ASK YOUR DOCTOR IF YOU HAVE
ANY QUESTIONS ABOUT WHY UREX
HAS BEEN PRESCRIBED FOR YOU.
Your doctor may have
prescribed

পণ্য বৈশিষ্ট্য

New Zealand Datasheet
Page 1 of 12
NEW ZEALAND DATA SHEET
UREX FORTE (FRUSEMIDE 500 MG TABLETS)
NAME OF THE DRUG:
Chemically, FRUSEMIDE it is 4-chloro-N-furfuryl-5-sulfamoylanthranilic
acid. The
chemical structure is below.
DESCRIPTION:
Frusemide is an anthranilic acid derivative. Frusemide is a
sulphonamide-type loop diuretic
and occurs as a white to slightly yellow, odourless crystalline powder
with a pKa of 3.9. It
is only slightly soluble in water, sparingly soluble in alcohol and
freely soluble in alkali
hydroxides.
Urex Forte tablets contain the following excipients; lactose,
starch-maize, silica-colloidal
anhydrous, magnesium stearate and maltodextrin.
Urex tablets and Urex-M tablets contain the following excipients;
lactose, maize starch and
magnesium stearate.
PHARMACOLOGY:
Frusemide is a potent diuretic. It inhibits sodium reabsorption in the
ascending limb of
Henle's loop and in both the proximal and distal tubules. The action
on the distal tubule is
independent of any inhibitory effect on carbonic anhydrase or
aldosterone. The high degree
of efficacy is due to this unique site of action.
Frusemide may promote diuresis in cases which have previously proved
resistant to other
diuretics.
Frusemide has no significant pharmacological effects other than on
renal function.
Frusemide is rapidly absorbed from the upper gastrointestinal tract.
Absorption rates in
healthy subjects have been reported from 60-69%; 45% in patients with
end stage renal
New Zealand Datasheet
Page 2 of 12
failure; and 34-80 in patients with congestive heart failure.
Bioavailability in healthy subjects is 60-69%.
The mean apparent volume of distribution in the steady state ranges
from 0.07 to 0.18 L/kg
body weight in healthy subjects.
Recent evidence suggests that frusemide glucuronide is the only or at
least the major
biotransformation product of frusemide in man. Frusemide is
extensively bound to plasma
99%
bound
in
healthy
individuals.
The
unbound
fraction
averages
2.3
to
4.1%
of
therapeutic concentrations.
Frusemide's diuretic effe