Country: মাল্যাশিয়া
ভাষা: ইংরেজি
সূত্র: NPRA (National Pharmaceutical Regulatory Agency, Bahagian Regulatori Farmasi Negara)
THEOPHYLLINE
PAHANG PHARMACY SDN. BHD.
THEOPHYLLINE
100Tablet Tablets
MODI-MUNDIPHARMA PRIVATE LIMITED
_CONSUMER MEDICATION INFORMATION LEAFLET (RIMUP)_ UNICONTIN TM CONTROLLED RELEASE TABLETS Theophylline (400mg, 600mg) _ _ 1 WHAT IS IN THIS LEAFLET 1. What Unicontin TM _ _is used for 2. How Unicontin TM works 3. Before you use Unicontin TM 4. How to use Unicontin TM 5. While you are using it 6. Side effects 7. Storage and Disposal of Unicontin TM 8. Product Description 9. Manufacturer and Product Registration Holder 10. Date of revision WHAT UNICONTIN TM IS USED FOR Unicontin TM is used to treat and prevent asthma and other conditions where breathing is difficult. HOW UNICONTIN TM WORKS Unicontin TM contains the active ingredient theophylline, which causes the airway muscle to relax and prevents inflammation. BEFORE YOU USE UNICONTIN TM - _When you must not use it _ Do not take Unicontin TM tablets: if you are allergic to theophylline, aminophylline or to any ingredients of this medicine (listed in Product Description). if you have porphyria (inherited genetic condition) in children under 6 years of age (less than 22kg) using medicine called ephedrine. in children under 6 months of age. - _Before you start use it _ Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes and /or if you have or ever had any other health problems, including: irregular or rapid heartbeat or any other heart problems any liver problems any lung or breathing problems thyroid problems fever any viral infections any stomach problems such as ulcer or acid reflux seizures very high blood pressure you have taken large amounts of alcohol or other substances which can affect your level of consciousness. elderly males that has urinary retention or at risk of developing one, for example in individual with prostate enlargement. Your doctor or pharmacist can discuss with you the risks and benefits involved. _Pregnancy and Lactation _ This medicine is not recommended for use in pregnancy. Consult your doctor before taking Unicontin TM tablets if you are সম্পূর্ণ নথি পড়ুন
For the use only of a Registered Medical Practitioner or a Hospital or a Laboratory R x Controlled Release Tablets of Theophylline UNICONTIN TM 400/600 CONTINUS TM controlled release system DESCRIPTION UNICONTIN TM 400/600 CONTINUS TM tablets for oral administration contain 400/600mg of theophylline BP in a controlled release system which allows a 24-hour dosing interval for appropriate patients. Unicontin 400: Each white, round, flat, bevelled edges, scored uncoated tablets engraved with ‘MM’ logo on one of the facets and 'U/400' on the other. Unicontin 600: Each white, biconvex, scored uncoated caplets engraved with ‘MM’ logo on one of the facets and 'U/600' on the other. CLINICAL PHARMACOLOGY Theophylline has two distinct actions: smooth muscle relaxation (e.g. bronchodilation) and suppression of the response of the airways to stimuli (i.e. non-bronchodilator prophylactic effects). Studies suggest that bronchodilation is mediated by the inhibition of two isozymes of phosphodiesterase (PDE III and to a lesser extent, PDE IV) while nonbronchodilator prophylactic actions are probably mediated through one or more different molecular mechanisms, that do not involve inhibition of PDE III or antagonism of adenosine receptors. Theophylline increases the force of contraction of diaphragmatic muscles. This action appears to be due to enhancement of calcium uptake through an adenosine-mediated channel. Serum Concentration-Effect Relationship: Theophylline is often thought of as a drug which has a particularly well-defined therapeutic range with concentration from 5-20 mcg/ml giving an optimum compromise between efficacy and toxicity. Maintaining the peak serum theophylline concentration between 10-15 mcg/ml, will achieve most of the drug therapeutic benefit with minimal risk & adverse effect. At serum theophylline concentrations >20mcg/mL, both the frequency and severity of adverse reactions increase. The pharmacokinetics of theophylline vary widely among similar patients and cannot be predicted by age, sex, body সম্পূর্ণ নথি পড়ুন