দেশ: নিউ জিলণ্ড
ভাষা: ইংরেজি
সূত্র: Medsafe (Medicines Safety Authority)
Travoprost 0.004%{relative}
Pharmaco (NZ) Ltd
Travoprost 0.004% w/v
0.004% w/v
Eye drops, solution
Active: Travoprost 0.004%{relative} Excipient: Boric acid Hydrochloric acid Hydrogenated castor oil Propylene glycol Purified water Sodium hydroxide Sorbitol Zinc chloride
Bottle, plastic, polypropylene dispenser bottle with dropper tip, 2.5 mL
Prescription
Prescription
Dr Reddy's Laboratories (EU) Ltd
Indicated to decrease elevated intraocular pressure in ocular hypertension and open-angle glaucoma.
Package - Contents - Shelf Life: Bottle, plastic, polypropylene dispenser bottle with dropper tip - 2.5 mL - 24 months from date of manufacture stored at or below 25°C. Do not freeze. 30 days opened - Bottle, plastic, polypropylene dispenser bottle with dropper tip - 5 mL - 24 months from date of manufacture stored at or below 25°C. Do not freeze. 30 days opened
2006-06-19
1 DATA SHEET TRAVATAN ® Z TRAVOPROST 0.004% EYE DROPS NAME OF THE DRUG TRAVATAN Z Eye Drops contain travoprost. The chemical structure of travoprost is: Molecular weight: 500.56 Empirical formula: C 26 H 35 F 3 O 6 Chemical name: (5Z,13E)-(9S,11R,15R)-9,11,15-Trihydroxy-16- (_m_- trifluoro methylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid, isopropyl ester CAS Number: 157283-68-6 DESCRIPTION Travoprost is a clear to slightly opalescent, colourless to yellow oil. Travoprost is practically insoluble in water (approximately 44 ppm). TRAVATAN Z Eye Drops have been formulated as a sterile solution for topical application to the eye. The buffered aqueous solution has a pH of approximately 6.0 and an osmolality of approximately 290 mOsmol/kg. TRAVATAN Z Eye Drops are preserved in the bottle with an ionic buffered system. TRAVATAN Z Eye Drops contain 40 µg/mL travoprost, together with boric acid, propylene glycol, polyoxyl 40 hydrogenated castor oil, sorbitol and zinc chloride, sodium hydroxide and/or hydrochloric acid to adjust pH, and purified water, USP. PHARMACOLOGY _PHARMACOKINETICS _ Travoprost is absorbed into the eye following topical ocular administration where it is hydrolysed to the active free acid. Following administration of 1.2 µg 3 H-travoprost in rabbits, the highest concentrations of radioactivity are found in the cornea, conjunctiva, aqueous humour and iris ciliary body. Maximum levels were observed 0.5-2 hours after instillation. Radioactivity concentrations in most ocular tissues declined with half-lives of less than 2 hours (> 10 h in cornea and lens). Systemic exposure is low. Maximum plasma concentrations of 0.08 ng equivalent/g were observed at 0.5 hours and declined rapidly thereafter. 2 The metabolic pathways of the acid parallel those of endogenous PGF 2α and are characterised by reduction of the 13-14 double bond, oxidation of the 15-hydroxyl and β-oxidative cleavage of the carboxylic acid chain. Following topical ocular administration of travoprost 0.004% Eye Drops, preserved w সম্পূর্ণ নথি পড়ুন