SILVER SULFADIAZINE cream

দেশ: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

SILVER SULFADIAZINE (UNII: W46JY43EJR) (SULFADIAZINE - UNII:0N7609K889)

থেকে পাওয়া:

Greenstone LLC

প্রশাসন রুট:

TOPICAL

প্রেসক্রিপশন টাইপ:

PRESCRIPTION DRUG

থেরাপিউটিক ইঙ্গিত:

Silver Sulfadiazine Cream 1% is a topical antimicrobial drug indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns. Silver Sulfadiazine Cream 1% is contraindicated in patients who are hypersensitive to silver sulfadiazine or any of the other ingredients in the preparation. Because sulfonamide therapy is known to increase the possibility of kernicterus, silver sulfadiazine cream 1% should not be used on pregnant women approaching or at term, on premature infants, or on newborn infants during the first 2 months of life.

পণ্য সারাংশ:

Silver Sulfadiazine Cream 1% is available in jars containing 50 g (NDC 59762-0131-6) and 400 g (NDC 59762-0131-4), and tubes containing 20 g (NDC 59762-0131-0), 25 g (NDC 59762-0131-2), 50 g (NDC 59762-0131-5) and 85 g (NDC 59762-0131-8). Store at Controlled Room Temperature 20° to 25°C (68° to 77°F).

অনুমোদন অবস্থা:

New Drug Application Authorized Generic

পণ্য বৈশিষ্ট্য

SILVER SULFADIAZINE- SILVER SULFADIAZINE CREAM
GREENSTONE LLC
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SILVER SULFADIAZINE CREAM 1%
DESCRIPTION
Silver Sulfadiazine Cream 1% is a soft, white, water-miscible cream
containing the
antimicrobial agent silver sulfadiazine in micronized form, which has
the following
structural formula:
Each gram of silver sulfadiazine cream 1% contains 10 mg of micronized
silver
sulfadiazine. The cream vehicle consists of white petrolatum, stearyl
alcohol, isopropyl
myristate, sorbitan monooleate, polyoxyl 40 stearate, propylene
glycol, and water, with
methylparaben 0.3% as a preservative. Silver Sulfadiazine Cream 1%
spreads easily and
can be washed off readily with water.
CLINICAL PHARMACOLOGY
Silver sulfadiazine has broad antimicrobial activity. It is
bactericidal for many gram-
negative and gram-positive bacteria as well as being effective against
yeast. Results
from _in vitro_ testing are listed below.
Sufficient data have been obtained to demonstrate that silver
sulfadiazine will inhibit
bacteria that are resistant to other antimicrobial agents and that the
compound is
superior to sulfadiazine.
Studies utilizing radioactive micronized silver sulfadiazine, electron
microscopy, and
biochemical techniques have revealed that the mechanism of action of
silver sulfadiazine
on bacteria differs from silver nitrate and sodium sulfadiazine.
Silver sulfadiazine acts
only on the cell membrane and cell wall to produce its bactericidal
effect.
RESULTS OF IN VITRO TESTING WITH SILVER SULFADIAZINE CREAM 1%
CONCENTRATION OF SILVER SULFADIAZINE NUMBER OF SENSITIVE STRAINS/TOTAL
NUMBER OF STRAINS TESTED
GENUS & SPECIES
50 ΜG/ML
100 ΜG/ML
_Pseudomonas aeruginosa_
130/130
130/130
_Xanthomonas (Pseudomonas) maltophilia_
7/7
7/7
_Enterobacter_ species
48/50
50/50
_Enterobacter cloacae_
24/24
24/24
_Klebsiella _species
53/54
54/54
_Escherichia coli_
63/63
63/63
_Serratia _species
27/28
28/28
_Proteus mirabilis_
53/53
53/53
_Morganella morganii_
10/10
10/10
_Providencia rettgeri_
2/2
2/2
_Providencia _species
1/1
1/1
_Proteus vulgar