NEOMYCIN AND POLYMYXIN B SULFATES, AND BACITRACIN ZINC- neomycin sulfate, polymyxin b sulfate and bacitracin zinc ointment

দেশ: মার্কিন যুক্তরাষ্ট্র

ভাষা: ইংরেজি

সূত্র: NLM (National Library of Medicine)

সক্রিয় উপাদান:

Neomycin Sulfate (UNII: 057Y626693) (Neomycin - UNII:I16QD7X297), Polymyxin B Sulfate (UNII: 19371312D4) (Polymyxin B - UNII:J2VZ07J96K), Bacitracin Zinc (UNII: 89Y4M234ES) (Bacitracin - UNII:58H6RWO52I)

থেকে পাওয়া:

Henry Schein Inc.

INN (আন্তর্জাতিক নাম):

Neomycin Sulfate

রচনা:

Neomycin 3.5 mg in 1 g

প্রশাসন রুট:

OPHTHALMIC

প্রেসক্রিপশন টাইপ:

PRESCRIPTION DRUG

থেরাপিউটিক ইঙ্গিত:

Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment. USP is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis. Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic Ointment, USP is contraindicated in individuals who have shown hypersensitivity to any of its components.

পণ্য সারাংশ:

Tube of 1/8 oz. (3.5 g) with ophthalmic tip. NDC 0404-7194-01 Storage: Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Distributed by (in US only): HENRY SCHEIN INC. 135 DURYEA ROAD MELVILLE, NY 11747 USA BNPB00N Rev. 10/15

অনুমোদন অবস্থা:

Abbreviated New Drug Application

পণ্য বৈশিষ্ট্য

NEOMYCIN AND POLYMYXIN B SULFATES, AND BACITRACIN ZINC- NEOMYCIN
SULFATE, POLYMYXIN B SULFATE AND BACITRACIN ZINC OINTMENT
HENRY SCHEIN INC.
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NEOMYCIN AND POLYMYXIN B SULFATES AND
BACITRACIN ZINC OPHTHALMIC OINTMENT, USP
Rx only
DESCRIPTION:
Neomycin and Polymyxin B Sulfates and Bacitracin Zinc Ophthalmic
Ointment, USP is a
sterile antimicrobial ointment for ophthalmic use. Each gram contains:
Neomycin Sulfate
(equivalent to 3.5 mg neomycin base), Polymyxin B sulfate equal to
10,000 polymyxin B
units, bacitracin zinc equal to 400 bacitracin units, and white
petrolatum, q.s.
Neomycin sulfate is the sulfate salt of neomycin B and C, which are
produced by the
growth of _Streptomyces fradiae_ Waksman (Fam. Streptomycetaceae). It
has a potency
equivalent of not less than 600 mcg of neomycin standard per mg,
calculated on an
anhydrous basis. The structural formula are:
Polymyxin B sulfate is the sulfate salt of polymyxin B and B , which
are produced by
the growth of _Bacillus polymyxa_ (Prazmowski) Migula (Fam.
Bacillaceae). It has a potency
of not less than 6,000 polymyxin B units per mg, calculated on an
anhydrous basis. The
structural formulae are:
Bacitracin zinc is the zinc salt of bacitracin, a mixture of related
cyclic polypeptides
(mainly bacitracin A) produced by the growth of an organism of the
_licheniformis_ group
of _Bacillus subtilis_ var Tracy. It has a potency of not less than 40
bacitracin units per mg.
The structural formula is:
1
2
CLINICAL PHARMACOLOGY
A wide range of antibacterial action is provided by the overlapping
spectra of neomycin,
polymyxin B sulfate, and bacitracin.
Neomycin is bactericidal for many gram-positive and gram-negative
organisms. It is an
aminoglycoside antibiotic, which inhibits protein synthesis by binding
with ribosomal RNA
and causing misreading of the bacterial genetic code.
Polymyxin B is bactericidal for a variety of gram-negative organisms.
It increases the
permeability of the bacterial cell membrane by interacting with the
phospholipid
components of the membr