MYLAN-PINDOLOL TABLET

Country: কানাডা

ভাষা: ইংরেজি

সূত্র: Health Canada

এখন এটা কিনুন

সক্রিয় উপাদান:

PINDOLOL

থেকে পাওয়া:

MYLAN PHARMACEUTICALS ULC

এটিসি কোড:

C07AA03

INN (International Name):

PINDOLOL

ডোজ:

10MG

ফার্মাসিউটিকাল ফর্ম:

TABLET

রচনা:

PINDOLOL 10MG

প্রশাসন রুট:

ORAL

প্যাকেজ ইউনিট:

100/500

প্রেসক্রিপশন টাইপ:

Prescription

Therapeutic area:

BETA-ADRENERGIC BLOCKING AGENTS

পণ্য সারাংশ:

Active ingredient group (AIG) number: 0112362003; AHFS:

অনুমোদন অবস্থা:

CANCELLED POST MARKET

অনুমোদন তারিখ:

2012-10-19

পণ্য বৈশিষ্ট্য

                                1
PRODUCT MONOGRAPH
MYLAN-PINDOLOL
(Pindolol Tablets, USP)
5 AND 10 MG
Antihypertensive/Antianginal Agent
Mylan Pharmaceuticals ULC
Date of Preparation:
85 Advance Road
August 19, 2010
Etobicoke, Ontario
M8Z 2S6
Control#: 140702
2
PRODUCT MONOGRAPH
MYLAN-PINDOLOL
(Pindolol Tablets, USP)
5 AND 10 MG
THERAPEUTIC CLASSIFICATION
Antihypertensive/Antianginal Agent
ACTIONS AND CLINICAL PHARMACOLOGY
Pindolol is a 13-adrenergic-receptor-blocking agent which possesses
partial agonist activity
(intrinsic sympathomimetic activity - I.S.A.). It is used in the
treatment of hypertension and/or
the prophylaxis of angina pectoris.
Hypertension
The mechanism of the antihypertensive effect of pindolol has not been
established. Among the
factors that may be involved are:
a)
competitive ability to antagonize catecholamine-induced tachycardia at
the 13-receptor
sites in the heart, thus decreasing cardiac output
b)
a reduction in total peripheral resistance
c)
inhibition of the vasomotor centres
d)
inhibition of renin release by the kidneys.
3
Angina pectoris
The mechanism of the antianginal effect of pindolol has not been
established. Pindolol may
reduce the oxygen requirement of the heart at any level of effort by
blocking catecholamine-
induced increases in the heart rate, systolic blood pressure, and the
velocity and extent of
myocardial contraction. However, oxygen requirements may be increased
by such actions as
increases in left ventricular fibre length, end diastolic pressure and
the systolic ejection period.
When the net effect is beneficial in patients with angina, it
manifests itself during exercise or
stress by delaying the onset of pain and reducing the incidence and
severity of anginal attacks.
In man, orally-administered pindolol is rapidly and almost completely
absorbed (95%). Because
of negligible hepatic first pass effect, the bioavailability of oral
pindolol is high and approaches
90% of the oral dose. Maximum plasma concentrations are reached one to
two hours after oral
administration and the plasma half-life is ap
                                
                                সম্পূর্ণ নথি পড়ুন
                                
                            

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